Prosthesis Infection and One-step Exchange: Pretreatment by Targeted Antibiotic Therapy in
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 13
- 试验地点
- 1
- 主要终点
- Rate of Treatment Failure
研究概览
简要总结
One-step exchange arthroplasty is more and more used in the treatment of chronic infections, especially in patients at risk anesthetic.
This strategy is not recommended in patients infected with multidrug-resistant organisms or difficult to treat because of a risk of bacterial persistence on the new implant.
Antibiotic pretreatment by a narrow-spectrum molecule and for which resistance acquisition is difficult might be of interest to try to reduce the inoculum and avoid contamination of the new implant.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 18 Years 至 100 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •patients having had a antibiotic pretreatment targeted before a one step exchange arthroplasty
排除标准
- 未提供
结局指标
主要结局
Rate of Treatment Failure
时间窗: Outcome is measured at the end of follow-up (usually between 12 and 24 months after antibiotic therapy disruption
Treatment failure is defined by local clinical and/or microbiological relapse; and/or need for additional surgery; death of septic origin
次要结局
- rate of bacteria responsible for infection(Outcome is measured at the end of follow-up (usually between 12 and 24 months after antibiotic therapy disruption)
- rate of use of this strategy(Outcome is measured at the end of follow-up (usually between 12 and 24 months after antibiotic therapy disruption)
研究者
Eugénie MABRUT
CRA
Hospices Civils de Lyon