Pseudo-PDT in Central Serous Chorioretinopathy
试验速览
- 阶段
- 不适用
- 入组人数
- 22
- 主要终点
- Central Retinal Thickness (micron)
研究概览
简要总结
Acute central serous chorioretinopathy (CSC) is a common disorder in middle-aged patients, characterized by serous retinal detachment in the macular region. We evaluated half-dose verteporfin photodynamic therapy (hd-PDT) versus 689 nm laser treatment in chronic CSC.
Twenty-two eyes of 22 patients with symptomatic chronic CSC were randomized in a 1:1 ratio to receive hd-PDT (group 1) or 689-LT delivering 95 J/cm2 by application of an intensity of 805 mW/cm2 over 118 seconds. Best-corrected visual acuity (BCVA) and spectral-domain optical coherence tomography findings were compared between groups.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •age ≥18 years;
- •patients with best-corrected visual acuity (BCVA) of 20/200 or better;
- •presence of subretinal fluid (SRF) and/or serous pigment epithelial detachment involving the fovea on optical coherence tomography (OCT);
- •presence of active angiographic leakage in fluorescein angiography caused by CSC and no other diseases, and abnormal dilated choroidal vasculature and other features in indocyanine green angiography (ICGA) consistent with the diagnosis of CSC.
排除标准
- •any previous treatment for CSC;
- •evidence of choroidal neovascularization or other maculopathy on fundus examination.
结局指标
主要结局
Central Retinal Thickness (micron)
时间窗: 6 months
Measured with OCT
Subfoveal Choroidal Thickness (micron)
时间窗: 6 months
Measured with OCT
Best-corrected Visual Acuity (LogMAR)
时间窗: 6 months
Measured with ETDRS chart
次要结局
- Ellipsoid Zone Recovery (integrity of IS/OS line)(6 months)
研究者
Andrea Russo
MD, PhD Candidate
Università degli Studi di Brescia