Phosphorus and Calcium Removal During Long Hemodialysis Treatment Sessions
试验速览
- 阶段
- 2 期
- 状态
- 撤回
- 主要终点
- the effect of dialysate volume and treatment time on phosphage and calcium removal
研究概览
简要总结
The purpose of this sudy is to determined the effect of dialysate volume and treatment time on phosphate and calcium removal in stage V chronickidney disease patients treated by hemodialysis using the System One (NxStage Medical, Lawrence, MA)
详细描述
Ten patients will be recruited from those routinely treated in-center or at home using the Systerm One at the clinical centers. Each patient will be studiesd on 4 separate occastions. Treatments under the following conditions will each be performed on each study patient, at least one week apart:
- Treatment for 8 hrs uding 40L of dialysate
- Treatment for 8 hrs using 60L of dialysate
- Treatment for 5 hrs using 40L of dialysate
- Treatment for 5 hrs using 60L of dialysate
Blood samples will be collected and assayed for the concentrations of urea, phosphate, calcium, bicarbonate, beta-2-microglobulin and albumin using standard assays.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Single Group
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Stage V chronic kidney patients with minimal or no residual renal functin
排除标准
- •Medically unstable
- •Hematocrit less than 28%
- •Hepatitis B positive, hepatitis C positive or HIV positive
- •Pregnant women
- •Minors below 18 years of age
- •Active psychiatric disease
结局指标
主要结局
the effect of dialysate volume and treatment time on phosphage and calcium removal
时间窗: 4 treatments
次要结局
未报告次要终点