Does subarachnoid administration of hyperbaric prilocaine produce an improved recovery from anaesthesia when compared with hyperbaric bupivacaine when used to make cervical cerclage easier in pregnant women at risk of pre-term loss?

Guy's and St Thomas' NHS Foundation Trust0 个研究点目标入组 135 人开始时间: 2021年2月8日最近更新: 2024年9月9日

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•Healthy (ASA score 1 or 2) women in the second trimester of pregnancy presenting for elective cervical cerclage under spinal anaesthesia

•1. Inability to read or understand the patient information sheet (PIS)
•2. Aged <18 years
•3. Unable or unwilling to consent to participation
•4. Non-elective procedure
•5. Serious co-morbidities (ASA score 3 or above)
•6. Any contraindication to SAB, e.g. local or generalised infection, active central nervous system disease, coagulation disorders or anti-coagulant medication
•7. Any history of allergic reaction to any of the medications in the protocol
•8. Concomitant use of class III antiarrhythmics (sulfonamides, antimalarials, sodium nitroprussate, nitroglycerin, other local anaesthetics)
•9. Any contraindication to the use of bupivacaine or prilocaine as listed in the SmPCs

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