ACTRN12613000372785尚未招募3 期
An investigation of the effects of Baclofen on the amount of high frequency beta activity during quantitative electroencephalography in alcohol dependent participants.
适应症
试验速览
- 阶段
- 3 期
- 状态
- 尚未招募
- 入组人数
- 20
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional
- 分配方式
- Non-randomised trial
- 主要目的
- Treatment
- 盲法
- Open (masking not used)
入排标准
- 年龄范围
- 18 Years 至 70 Years（—）
- 性别
- All
入选标准
- •Severe Alcohol Use Disorder
- •Abstinent from alcohol for 1 week
- •Willing and able to provide informed consent to participate in the study
排除标准
- •1.Opiate, Stimulant, Inhalant or Benzodiazepine dependence
- •2.History of dementia or severe brain injury or Mini Mental score < or = 26/30
- •3.Receiving baclofen or diazepam medication in the 5 days prior to the study
- •4.Receiving any regular medication which may significantly change EEG activity including anticonvulsants, benzodiazepines or other sedatives. (This specifically does not include oral contraceptives, thiamine, multivitamins, thyroxine, naltrexone, nicotine replacement therapy or antidepressants.)
- •5.Acamprosate ( A medication for alcohol dependence which has a mechanism of action which could interact with the mechanism of action of Baclofen)
- •6. Renal function where creatinine clearance is less than 50ml/min.
- •7.Pregnancy or breast feeding
- •8.History of intolerance to baclofen
- •9.Contraindications/precautions ( as listed in the product information) to baclofen
- •10.Past history of major medical condition.
研究者
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