ISRCTN26944158已完成2 期
A randomised trial of single dose oral dexamethasone versus multi-dose prednisolone in the treatment of acute exacerbations of asthma in children who attend the Emergency Department
ational Children’s Research Centre0 个研究点目标入组 286 人开始时间: 2010年6月18日最近更新:
适应症
试验速览
- 阶段
- 2 期
- 状态
- 已完成
- 发起方
- 入组人数
- 286
研究概览
简要总结
- 2012 protocol in http://www.ncbi.nlm.nih.gov/pubmed/22909281
研究设计
- 研究类型
- Interventional
入排标准
- 性别
- All
入选标准
- •1. Aged 2 - 16 years, either sex
- •2. Presentation with acute asthma, defined as:
- •2.1. At least two previous episodes of beta-2-agonist responsive wheeze in a child 2 years of age or over
- •2.2. A prior diagnosis of asthma, made by a paediatrician, or clinician of comparable experience
- •3. Present to the ED of Our Ladys Childrens Hospital, Crumlin (OLCHC), Dublin, Ireland
排除标准
- •1. Less than 2 years old or over 16 years
- •2. Previous enrolment in the study
- •3. Critical or life threatening asthma
- •4. Known tuberculosis (TB) exposure
- •5. Active varicella or herpes simplex infection
- •6. History of acute allergic reaction
- •7. Documented concurrent infection with respiratory syncytial virus (RSV)
- •8. Fever greater than 39.5°C
- •9. Use of oral corticosteroids or admission for asthma in the previous 4 weeks
- •10. Concurrent stridor
- •11. Possible intrathoracic foreign body
- •12. Significant co-morbid disease, i.e., lung, cardiac, immune, liver, endocrine, neurological or psychiatric
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