Dynamic Changes in Carotid Artery Doppler Parameters Following Passive Leg Raising for Prediction of Post-Induction Hypotension in Patients Undergoing Elective Gastrointestinal Tumor Surgery
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 入组人数
- 99
- 试验地点
- 1
- 主要终点
- Predictive performance of dynamic changes in carotid Doppler parameters (ΔVTI, ΔPSV, ΔFTc) for post-induction hypotension
研究概览
简要总结
This prospective study aims to investigate the role of the passive leg raise maneuver prior to anesthesia induction in predicting post-induction hypotension among elective gastrointestinal tumor surgery patients using carotid artery Doppler parameters.
详细描述
The study will be conducted on patients scheduled for elective gastrointestinal tumor surgery. Prior to anesthesia induction, a passive leg raise maneuver will be performed. Carotid artery Doppler parameters and hemodynamic changes will be measured and recorded to evaluate their efficacy in predicting subsequent post-induction hypotension.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Adults aged 18 years or older
- •Patients scheduled for elective gastrointestinal tumor surgery
- •Surgery planned under general anesthesia
- •Body mass index (BMI) <40 kg/m²
- •Written informed consent provided
排除标准
- •Refusal to participate or inability to obtain written informed consent
- •BMI ≥40 kg/m²
- •Pregnancy
- •Emergency surgery
- •Difficult intubation
- •ASA physical status ≥IV
- •Pediatric patients (<18 years)
- •Inability to perform carotid Doppler measurements
- •Arrhythmia other than continuous sinus rhythm or uncontrolled cardiac arrhythmia
- •Severe cardiac dysfunction or left ventricular ejection fraction <40%
- •Severe valvular heart disease
- •Clinically significant autonomic nervous system disorders
- •Inadequate noninvasive blood pressure monitoring or inability to obtain the required hemodynamic measurements
- •Active sepsis or systemic inflammatory syndrome
- •Severe peripheral vascular disease or significant carotid artery stenosis (>50%)
- •Severe pulmonary disease or advanced respiratory failure
- •Implanted cardiac device (pacemaker/ICD)
- •Baseline mean arterial pressure (MAP) <65 mmHg
- •Preoperative systolic blood pressure >190 mmHg or diastolic blood pressure >110 mmHg
研究组 & 干预措施
Elective Gastrointestinal tumor surgery group
Patients scheduled for elective gastrointestinal tumor surgery under general anesthesia who undergo preoperative carotid Doppler assessment and a passive leg raising (PLR) maneuver
结局指标
主要结局
Predictive performance of dynamic changes in carotid Doppler parameters (ΔVTI, ΔPSV, ΔFTc) for post-induction hypotension
时间窗: From pre-induction passive leg raising assessment to 20 minutes after general anesthesia induction
Evaluation of the predictive performance of percentage changes in carotid artery velocity time integral (ΔVTI), peak systolic velocity (ΔPSV), and corrected flow time (ΔFTc) after passive leg raising maneuver for post-induction hypotension
次要结局
- Association of baseline carotid Doppler parameters with post-induction hypotension(From pre-induction assessment to 20 minutes after general anesthesia induction)
- Cut-off values of changes in carotid Doppler parameters for prediction of post-induction hypotension(From pre-induction passive leg raising assessment to 20 minutes after general anesthesia induction)
- Association of carotid Doppler changes with duration and severity of hypotension(From general anesthesia induction to 20 minutes post-induction)
- Association of carotid Doppler changes with vasopressor requirement(From general anesthesia induction to 20 minutes post-induction)
研究者
Seçilnaz Ünlü Tuncer
MD
Ankara City Hospital Bilkent