ACTRN12623000227695尚未招募3 期
Selective serotonin reuptake inhibitors And Depression in Atrial Fibrillation: the SAD-AF randomised controlled trial of escitalopram vs placebo in patients with AF and depression evaluating AF-related quality of life
适应症
试验速览
- 阶段
- 3 期
- 状态
- 尚未招募
- 入组人数
- 154
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomised controlled trial
- 主要目的
- Treatment
- 盲法
- Blinded (masking used)
入排标准
- 年龄范围
- 18 Years 至 85 Years（—）
- 性别
- All
入选标准
- •Age greater than or equals to 18 years old
- •Paroxysmal AF (atrial fibrillation and/or flutter), with minimum 2 episodes in the last 6 months or persistent AF requiring direct cardioversion
- •Score of >=5/27 on the PHQ-9.
排除标准
- •Presence of significant psychiatric comorbidity where it is considered unsafe to alter current treatment regimen
- •Presence of significant cognitive impairment
- •Inability or unwillingness to provide informed consent
- •Permanent AF (where sinus rhythm cannot be restored)
- •Advanced heart failure, as defined by left ventricular ejection fraction < 35%.
- •Severe renal impairment defined as creatinine clearance <=30ml/min
- •Hepatic impairment defined as the presence of cirrhosis
- •Life expectancy <= 24 months due to co-morbid non-cardiac illness, including liver failure, end-stage renal disease or advanced malignancy.
- •Age > 85 years-old
- •Critically unwell patients.
研究者
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