ISRCTN28343638已完成不适用
Histamine Release and Implications of H1- and H2-Blockade in Adult Cardiac Surgery - A Randomised Controlled Study
niversity of Wales College of Medicine, UK0 个研究点目标入组 80 人开始时间: 2005年1月31日最近更新:
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 80
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional
入排标准
入选标准
- •Entry criteria: Patients presenting for elective coronary artery bypass grafting (CABG) and valve surgeries using cardiopulmonary bypass.
排除标准
- •1. Patients on heparin or nitrate infusions
- •2. Patients with known allergies
- •3. Known asthmatics and patients with severe chronic obstructive pulmonary disease (COPD)
- •4. Patients on steroids or other immunosuppressive drugs
- •5. Emergency procedures or re-do operations
- •6. Patients on regular H1 or H2 blockers
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Histamine Release and Implications of H1- and H2- Blockade in Adult Cardiac Surgery - A Randomised Controlled Study - Implications of H1- and H2- Blockade in Adult Cardiac SurgeryDuring cardiac surgery involving the use of cardiopulmonary bypass histamine is released in the blood. Histamine release has been related to an increased incidence of perioperative dysrhythmias and may be involved in other complications. Our aim is to find out whether the use of histamine blocking drugs will prevent these arrhythmias. The study population will consist of adult patients who must undergo elective cardiac surgery in which the use of cardiopulmonary bypass is necessaryEUCTR2005-001291-12-GBCardiff University80
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