Identification of Regional Epidemiological Characteristics and Key Prognostic Factors of Colorectal Cancer in Xinjiang and Shandong: A Multicenter, Retrospective Study
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 500
- 试验地点
- 1
- 主要终点
- 5-year Overall Survival
研究概览
简要总结
This is a multicenter, retrospective, cross-sectional observational study aiming to investigate the 5-year overall survival (OS) rate of colorectal cancer (CRC) patients in Xinjiang and Shandong provinces of China. A total of no less than 500 pathologically confirmed CRC patients from 7 medical centers during January 1, 2016 to December 31, 2020 will be enrolled. We will collect and analyze the demographic characteristics, lifestyle, clinical pathological features, treatment patterns and survival prognosis data of patients, explore the regional differences of CRC and its key prognostic factors, and construct a CRC prognostic prediction model. The results will provide theoretical guidance for clinical practice and the formulation of public health policies.
详细描述
Colorectal cancer is one of the most common malignant tumors with obvious regional distribution differences in incidence and prognosis. There are significant differences in economic development, lifestyle, dietary structure and medical resource allocation between Xinjiang (western China) and Shandong (eastern China), which may lead to different epidemiological characteristics and prognosis of CRC patients in the two regions. This study will enroll CRC patients from 7 multicenters in Xinjiang and Shandong, collect retrospective clinical data including demographic information, pathological features, treatment modes and follow-up records, use statistical methods such as Kaplan-Meier survival analysis and Cox proportional hazard regression model to analyze the 5-year OS rate and prognostic factors of patients in the two regions, compare the regional differences of CRC, and construct a Nomogram prognostic prediction model. The study will provide a scientific basis for the personalized treatment and regional public health prevention and control of CRC.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Crossover
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 18 Years 至 120 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •1. Pathologically confirmed colorectal adenocarcinoma.
- •2. Patients diagnosed between January 1, 2016 and December 31,
- •3. Age ≥ 18 years old.
- •4. Complete clinical, pathological, treatment and follow-up data available.
- •5. Patients from medical centers in Xinjiang and Shandong regions.
排除标准
- •1. Other pathological types of malignant tumors except colorectal adenocarcinoma.
- •2. Patients with incomplete clinical data or lost to follow-up.
- •3. Patients with severe organ dysfunction or other malignant tumors that may affect survival.
- •4. Age < 18 years old.
研究组 & 干预措施
Group/Cohort Label 1：Xinjiang CRC Cohort
Retrospective collection and analysis of clinical, pathological and follow-up data of pathologically confirmed colorectal cancer patients from medical centers in Xinjiang region, including demographic characteristics, lifestyle, treatment patterns and 5-year overall survival status.
干预措施: Retrospective Data Collection (Other)
Group/Cohort Label 2：Shandong CRC Cohort
Retrospective collection and analysis of clinical, pathological and follow-up data of pathologically confirmed colorectal cancer patients from medical centers in Shandong region, including demographic characteristics, lifestyle, treatment patterns and 5-year overall survival status.
干预措施: Retrospective Data Collection (Other)
结局指标
主要结局
5-year Overall Survival
时间窗: 5 years
Five-year overall survival rate of patients with colorectal cancer, defined as the time from pathological diagnosis to death from any cause or last follow-up.
次要结局
未报告次要终点