NCT01838356已完成不适用
Intracranial Atherosclerosis and Predictors of Post-CABG Depression
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 169
- 试验地点
- 2
- 主要终点
- Pre-surgical intracranial atherosclerosis as measured by transcranial doppler ultrasound relative to depressive symptoms post-surgically as measured by DISH.
研究概览
简要总结
The purpose of the study is to examine if blood flow in the brain before coronary artery bypass graft surgery has an effect on depression after surgery.
The main hypothesis of the study states that pre-surgical blood flow in the brain will be an independent risk factor for depression after surgery after adjusting for other risk factors such as gender, pre-CABG depression, social support, medical comorbidity burden, socioeconomic status, and neuroticism.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Only
- 时间视角
- Prospective
入排标准
- 年龄范围
- 40 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Age: 40 years or older
- •Will be having CABG surgery at the Yale New Haven Hospital
- •Be able to provide informed consent
- •Have a household telephone
- •A fluent English speaker, and possessing no communication barrier
- •Be able to come to the study site or to have the study team come to his/her home.
- •Has a family member or partner/ friend who could provide collateral information
排除标准
- •Has had previous CABG surgery
- •History of dementia diagnosis or cognitive impairment (CDR >/= 1)
- •Auditory or visual impairment that would interfere with study procedures
- •Active alcohol or substance abuse problem based CAGE-AID (endorsing two or more items)
- •History of Bipolar Disorder, Schizophrenia, Schizoaffective Disorder, or any Psychotic Disorder by medical history or self-report.
- •Presence of non-cardiovascular conditions likely to be fatal within 1 year
结局指标
主要结局
Pre-surgical intracranial atherosclerosis as measured by transcranial doppler ultrasound relative to depressive symptoms post-surgically as measured by DISH.
时间窗: 12 months
次要结局
- Examine neurocognitive function relative to post-CABG depression through a series of neurocognitive tests.(12 months)
研究者
研究点 (2)
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