Advanced Perfusion MRI of Treatment Response and Progression in Glioblastoma
试验速览
- 阶段
- 不适用
- 状态
- 终止
- 入组人数
- 16
- 试验地点
- 1
- 主要终点
- A novel high resolution DSC-PWI imaging method
研究概览
简要总结
The primary aim of this project is to Compare new msCS and standard DSC-PWI methods in GBM patients undergoing post-operative MRI for monitoring of tumor progression.
详细描述
Investigators will compare the novel to the standard DSC-PWI methods in twenty five GBM patients to determine whether novel method improves image quality in tumor regions. We will also compare accuracy of pseudoprogression (PsP) vs. early progressive disease (ePD) determinations by the two techniques. If successful, the project will culminate in a novel imaging method sequence optimized to monitor progression and guide treatment decisions in post-operative GBM patients.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Only
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 82 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Histology: Glioblastoma (grade 4 astrocytoma)
- •Standard-of-care, post-gd T1w image changes suggestive or consistent with of progression.
- •Standard-of-care MRI included conventional DSC-PWI without unexpected technical difficulties.
- •Methylation status of tumor available in medical record.
- •Able to provide written informed consent.
排除标准
- •Contraindications either to 3T MRI (e.g. certain metallic and electronic implants, claustrophobia) or IV gadolinium contrast (allergy, pregnancy, breast-feeding, renal insufficiency). Screening for these contraindications will be based on history only (as it is for all routine outpatient clinical MRI at UWHC).
- •Significant physical or mental disease which would preclude successful compliance and participation in the study or, in the opinion of the principal investigator, or co-investigator, constitute a hazard, such that enrollment in the study would not be in the patient's best interest.
- •Special subjects such as minors, mentally disabled persons, or prisoners.
结局指标
主要结局
A novel high resolution DSC-PWI imaging method
时间窗: 2 years
A novel high resolution DSC-PWI method will be compared to the standard DSC-PWI method to determine whether novel method improves image quality in tumor regions.
次要结局
未报告次要终点