Cell free DNA and its receptor TLR9: a possible marker for periodontal disease status in smokers and non-smokers.
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 发起方
- 入组人数
- 60
- 试验地点
- 1
- 主要终点
- Difference in salivary or gingival crevicular fluid (GCF) levels of cell-free DNA and TLR9 expression between smokers, non-smokers, and healthy controls, and their correlation with periodontal disease severity.
研究概览
简要总结
Informed consent was obtained from the patients who are willing to participate in the study. GCF samples will collected from all subjects followed by the recording of clinical parameters at baseline. Patients in group 2 and 3 will further receive standard periodontal therapy as deemed necessary after the baseline recordings and GCF collection.
研究设计
- 研究类型
- Observational
入排标准
- 年龄范围
- 18.00 Year(s) 至 60.00 Year(s)（—）
- 性别
- All
入选标准
- •Group 1:Periodontal health with intact periodontium (healthy) Group 2:Subjects with Stage II-IV generalized periodontitis.
- •Group 3: Subjects with the habit of smoking nicotine cigarettes with periodontitis.
排除标准
- •Patients with any systemic disease.
- •Former smokers.
- •People using other forms of smoking along with cigarettes.
- •Patients undergoing orthodontic treatment.
- •Pregnancy or lactation.
- •Patients with history of periodontal therapy within past 3 months.
- •Patients with history of antibiotic intake within past 3 months.
- •Patients with history of anti-inflammatory drug therapy within 3 months.
- •Patients with any intra oral lesions.
结局指标
主要结局
Difference in salivary or gingival crevicular fluid (GCF) levels of cell-free DNA and TLR9 expression between smokers, non-smokers, and healthy controls, and their correlation with periodontal disease severity.
时间窗: Difference in salivary or gingival crevicular fluid (GCF) levels of cell-free DNA and TLR9 expression between smokers, non-smokers, and healthy controls, and their correlation with periodontal disease severity.
次要结局
- Changes in periodontal clinical parameters (PPD, CAL, BOP, PI, GI) after therapy.
研究者
Dr Sruthy Sudir
Vydehi Institute of Dental Sciences and Research Centre