Randomized Comparison of Continuous and Intermittent Heparin Infusion During Catheter Ablation of Atrial Fibrillation
试验速览
- 阶段
- 3 期
- 状态
- 已完成
- 发起方
- 入组人数
- 296
- 试验地点
- 1
- 主要终点
- therapeutic ACT retention rate during procedure
研究概览
简要总结
Optimal anticoagulation using heparin with close attention to maintain therapeutic dosing during the procedure is important.
Randomized comparison of continuous and intermittent heparin infusion during catheter ablation of Atrial Fibrillation.
详细描述
Intravenous heparin was used during the procedure to prevent catheter-induced thrombosis.
heparin is administered during the procedure to achieve recommended activation clotting times (ACT) values, typically >300 seconds to prevent thromboemboli during the procedure.
Most of the practitioners was that ACT level should be checked at 30- to 60-minute intervals and then have injected intermittently.
intermittent heparin infusion, concentration is great changed because the heparin has 30minutes half-period.
researchers postulate that a constant therapeutic concentrations would be beneficial to continuous infusion than intermittent infusion.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Single (Participant)
入排标准
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Atrial Fibrillation, Radiofrequency catheter ablation scheduled
排除标准
- •Clinical trial denied
研究组 & 干预措施
Continuous heparin infusion group
continuous group is given an initial intravenous heparin 100u/kg and then maintain heparin infusion during procedural.
干预措施: Continuous heparin infusion (Drug)
Intermittent heparin infusion group
Intermittent group is given an initial intravenous heparin 100u/kg. Then The ACT is tested every 30min with administration of additional heparin boluses and titration of the heparin drip based on the results and according to the judgment of the operating physician.
干预措施: Intermittent heparin infusion (Drug)
结局指标
主要结局
therapeutic ACT retention rate during procedure
时间窗: 2 years
次要结局
未报告次要终点
研究者
Yong Seog Oh
Professor
Seoul St. Mary's Hospital