Comparison of Azithromycin or Clarithromycin in 3drugs Protocol of H-pylori Eradication Regimen
试验速览
- 阶段
- 4 期
- 状态
- 已完成
- 入组人数
- 78
- 试验地点
- 1
- 主要终点
- H-pylori cinfirmation
研究概览
简要总结
The Aim of this study is comparison between two regimens containing clarithromycinand azithromycin.
详细描述
Eradication of helicobacter pylori is important for treatment of GU but ideal regimen is not available.
HP is resistant to metronidazole and clarithromycin, thus clarithromycin is expensive and it is not available in underdevelopment countries.
There are different articles about replacement clarithromycin with azithromycin as a method of eradication of HP that is decreases length of therapy and increases, effectiveness of drugs and decreases resistance of drugs.
The Aim of this study is comparison between two regimens containing clarithromycinand azithromycin.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Double (Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 20 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •patients with peptic ulcer due to H-pylori confirmed endoscopy and biopsy
排除标准
- •patients who got H-pylori eradication treatment previously
- •patients who used study drugs during 3months before study
研究组 & 干预措施
azithromycin
Azithromycin (Zithromax, Azithrocin ) is an azalide, a subclass of macrolide antibiotics. Azithromycin is one of the world's best-selling antibiotics. It is derived from erythromycin, with a methyl-substituted nitrogen atom incorporated into the lactone ring, thus making the lactone ring 15-membered.
干预措施: azithromycin (Drug)
clarithromycin
Clarithromycin is a macrolide antibiotic used to treat pharyngitis, tonsillitis, acute maxillary sinusitis, acute bacterial exacerbation of chronic bronchitis, pneumonia (especially atypical pneumonias associated with Chlamydophila pneumoniae), skin and skin structure infections. In addition, it is sometimes used to treat legionellosis, Helicobacter pylori, and lyme disease.
干预措施: clarithmycin (Drug)
结局指标
主要结局
H-pylori cinfirmation
时间窗: 1-3 months before study
confirmation is by endoscopy and biopsy
次要结局
- h-pylori eradication confirmation(two months after completion of 14 days standard treatment)
- side effect of study srugs(during 14 days standard treatment)
研究者
Behnam Baghianimoghadam
research consultant
Shahid Sadoughi University of Medical Sciences and Health Services