Investigating Inter-individual Variability in Glycemic and Insulin Responses
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 75
- 试验地点
- 2
- 主要终点
- Postprandial glycemic and insulin responses
研究概览
简要总结
This study aims to test the following hypothesis in healthy lean young men:
- There are differences in glycemic response (GR) and insulin response (IR) between Chinese, Malay and Asian-Indian
- There are differences in GI values to the same food between ethnic groups
- There are ethnic differences postprandial GR and IR for high vs low GI foods
- Mastication, salivary amylase activity, gastric emptying rate and gut microbiota composition influences inter-individual glycemic and insulinemic variability
- Ethnic differences in mastication, salivary amylase activity, gastric emptying rate and gut microbiota composition determines the inter-ethnic glycemic and insulinemic variability
详细描述
There is extensive evidence that numerous biological digestive factors varies between individuals and influence postprandial glycemic response (GR) and insulin response (IR), which are well established risk factors that precipitate the development of Type 2 diabetes mellitus (T2DM). However, no study to date has measured and compared physiological parameters such as mastication, salivary amylase activity, gastric emptying rates and gut microbiota in a multi-ethnic Asian population, with varying prevalence of obesity and T2DM. The aim of this study is to investigate ethnic differences in GR and IR as well as the GI values of foods. Additionally, we aim to examine how physiological digestive factors contribute to inter-ethnic and inter-individual variability in GR and IR. The study outcomes can potentially explain, in part, the varying susceptibility to obesity, T2DM and DM control between Chinese, Malays and Asian-Indians in Singapore, as reflected by the differences in prevalence of obesity, T2DM and DM control among the three local ethnic groups.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 21 Years 至 40 Years（Adult）
- 性别
- Male
- 接受健康志愿者
- 是
入选标准
- •Be willing and able to comply with study procedures and given written informed consent
- •Chinese/Malay/Indian males, aged 21-40 years old
- •Body mass index (BMI) between 18.5 - 24.9 kg/m2
- •Fasting blood glucose between 4 - 6 mmol/L
- •Sedentary adults, with <1 episode of exercise per week
- •Not have a history of food allergies or food intolerances
- •Be a non-smoker
- •Drinks less than 3 units of alcohol per day
- •Not taking antibiotics for the past 3 weeks
排除标准
- •Subjects with known chronic diseases, including diabetes, untreated hypertension, renal impairment, gastrointestinal problems, and other significant medical conditions
- •BMI <18.5 kg/m2 or >25 kg/m2
- •Fasting blood glucose ≥7.0mmol/l
- •Alcohol consumption >3 drinks / day
- •Use of medications known to affect glucose metabolism
- •Recent changes in weight of >5% over the past 3 months
- •Significant changes in diet over the past 3 months
- •History of eating disorders or irregular eating habits
- •Taking antibiotics medications over the past 3 weeks
研究组 & 干预措施
Glucose
Glucose anhydrous 50g dissolved in 250ml water
Jasmine rice
50g available carbohydrate portion
干预措施: Jasmine rice (Other)
Parboiled basmati rice
50g available carbohydrate portion
干预措施: Parboiled basmati rice (Other)
结局指标
主要结局
Postprandial glycemic and insulin responses
时间窗: Every 15 mins in the first hour and every 30 mins for the next 2 hours after food consumption
Capillary bloods will be obtained using finger-pricks
次要结局
- Physiological digestive functions(Up to 5 hours)
研究者
Lee Yung Seng
Associate Professor
Institute for Human Development and Potential (IHDP), Singapore