Pattern of Gait and Assessment Regarding Pathophysiology and Mechanism and Its Relation to Cognition, VEP, and Radiology as Prediction of Progression of Disease in Multiple Sclerosis Patients
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 入组人数
- 70
- 主要终点
- Mean gait velocity
研究概览
简要总结
This cross-sectional study aims to assess the pattern of gait in patients with multiple sclerosis and to evaluate its relation to cognitive function, visual evoked potentials, and radiological findings.
详细描述
Gait impairment is a common and disabling feature of multiple sclerosis. This observational study will include patients with confirmed multiple sclerosis according to the revised McDonald criteria who are clinically stable.
Participants will undergo quantitative gait analysis, cognitive assessment, visual evoked potential testing, and review of MRI findings in a single assessment visit.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Only
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 18 Years 至 55 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •- Age 18 to 55 years
- •Confirmed diagnosis of multiple sclerosis according to the revised McDonald criteria
- •Clinically stable (no relapse or steroid treatment within 4 weeks)
- •Able to walk independently with or without a single assistive device
- •Written informed consent
排除标准
- •- Other neurological, orthopedic, visual, or vestibular conditions affecting gait
- •Severe cognitive impairment precluding valid testing
- •Pregnancy
- •MRI contraindications
- •Ocular disease unrelated to multiple sclerosis
研究组 & 干预措施
Single cohort: Multiple Sclerosis Patients
Patients with confirmed multiple sclerosis who will undergo gait analysis, cognitive testing, visual evoked potential assessment, and MRI review in a single visit.
结局指标
主要结局
Mean gait velocity
时间窗: Baseline
Mean gait velocity in meters per second measured by quantitative spatiotemporal gait analysis.
次要结局
- Mean cadence(Baseline)
- Mean stride length(Baseline)
- Mean MoCA score(Baseline)
- Mean P100 latency(Baseline)
- Mean EDSS score(Baseline)
研究者
Manar Moataz Abdel-ghani
Resident Physician, Department of Neuropsychiatry
Assiut University