Pathophysiology of Gas Exchange and Time Course Changes in Spontaneously Breathing Patients With Acute Respiratory Failure Due to COVID-19. A Multicenter Prospective Study.
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- CHU de Reims
- 入组人数
- 59
- 试验地点
- 1
- 主要终点
- Association between measurement of intrapulmonary right-to-left shunt, ventilatory ratio and need to intubation.
研究概览
简要总结
The pathophysiology of SARS-COV-2 related respiratory disease is still poorly understood, especially in its most severe form called acute respiratory distress syndrome (ARDS). In this case, very few studies have investigated changes in gas exchange during COVID-19 progression in spontaneously breathing patients. The investigators purpose in this study to explore the pathophysiology of gas exchange and time course changes in spontaneously breathing patients with acute respiratory failure due to COVID-19. Moreover, our aim is to identify early markers associated with worsening respiratory failure and requiring endotracheal intubation.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Diagnostic
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients with a COVID-19 confirmed infection.
- •Admission in intensive care unit for an acute respiratory failure requiring oxygen flow above 6l/min by facial mask.
- •Presence of an arterial catheter for blood sampling.
排除标准
- •Patients on mechanical ventilation on admission to the ICU.
- •Patients requiring immediate intubation on admission.
- •Patients admitted to the ICU for more than 48 hours at the time of inclusion.
- •Pulmonary embolism diagnosed before admission to the ICU.
- •Minor patients
- •Pregnant women
- •Patients under curatorship or guardianship
- •Persons deprived of liberty by a judicial or administrative decision
研究组 & 干预措施
Respiratory insufficiency
Subject with respiratory insufficiency
干预措施: Pathophysiology of gas exchange (Other)
结局指标
主要结局
Association between measurement of intrapulmonary right-to-left shunt, ventilatory ratio and need to intubation.
时间窗: Lenght of hospital stay in intensive care unit
From date of admission in intensive care unit (ICU) until the date of death or disharge from ICU, assessed up to 90 days
次要结局
- Association between measurement of intrapulmonary right-to-left shunt, ventilatory ratio and mortality at D90.(Day 90)
- Association between measurement of intrapulmonary right-to-left shunt, ventilatory ratio and mortality at D28.(Day 28)
- Association between intrapulmonary right-to-left shunt, ventilatory ratio with percentage of lung damage on chest CT-scan.(At admission)