A Randomised Control Trail to compare the infection rate in topical use of antibiotic vs conventional management of open fractures groups.

Results: We recorded a significant reduction of infection rate on the 2nd and 6th week, but non-significant reduction at 6th month in the topical group compared to the non-topical group. As comparted to the non-topical group, in the topical group we recorded the reduced number of procedures, the length of hospital stay, and the rate of non-unions at 6-month follow-up. A specific feature of our participants was long delay tothefisrt debridement. Our study contributed to building evidence that adding topical antibiotic to standard protocol reduce infection rate in open fractures.