Study of Hybrid Training on Lipid Profile and Non-alcoholic Fatty Liver Disease in Middle-aged Obese Women
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 15
- 试验地点
- 1
- 主要终点
- Body Weight
研究概览
简要总结
Modern living and physical inactivity results in many ailments, including obesity, non-alcoholic fatty liver disease (NAFLD), and inflammatory issues.
Though there are a lot of studies on physical training, there is little detail on hybrid training or electrical and voluntary contractions of the musculature. This study investigated the efficiency of hybrid training in biochemistry, ultrasound, and proinflammatory outcomes in middle-aged sedentary and obese women with NAFLD.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Supportive Care
- 盲法
- None
入排标准
- 年龄范围
- 45 Years 至 65 Years（Adult, Older Adult）
- 性别
- Female
- 接受健康志愿者
- 是
入选标准
- •Sedentary women with one to two exercise sessions or less per month
- •BMI equal to or above 30 kg/m-2
- •WHR equal or above 0.85 m
- •Confirmed NAFLD, with grade 2 and 3
- •Systolic blood pressure not less than 130 mm Hg and diastolic blood pressure not less than 85 mm Hg
- •Increased AST and ALT
- •Mean age 45-65 years
排除标准
- •Use of 140 grams or more of ethanol per week
- •History of depression in the last 6 months
- •History of chronic or acute viral hepatitis
- •Drug-related liver disease and chronic liver disease
- •History of diabetes
- •Uncontrolled hypertension
- •Myocardial infarction
- •Chronic kidney disease
- •Hyperthyroidism or heart failure
- •Those who have weight loss programs or medical contraindications for physical training
- •Serious arterial hemorrhagic disorders
- •Serious neurological diseases
- •Advanced atherosclerosis
- •Elevated fever
结局指标
主要结局
Body Weight
时间窗: Pre-study
in kg
Body Mass Index
时间窗: Pre-study
in kg/m-2
Aspartate transaminases
时间窗: Pre-study
in u/l
Alanine transaminases
时间窗: Pre-study
in u/l
Fasting blood sugar
时间窗: Pre-study
in mg/dl
HDL Cholesterol Plasma
时间窗: Pre-study
in mg/dl
Proinflammatory cytokine (interleukin -6)
时间窗: Pre-study
in pg/ml
Ultrasonic assessment
时间窗: Pre-study
Grade of liver steatosis
WHR
时间窗: Pre-study
Waist-to-hip ratio in cm
SBP/DBP
时间窗: Pre-study
Systolic blood pressure/Diastolic blood pressure
次要结局
- Body Weight(six-week)
- Body Mass Index(six-week)
- Aspartate transaminases(six-week)
- HDL Cholesterol Plasma(six-week)
- Alanine transaminases(six-week)
- Fasting blood sugar(six-week)
- Proinflammatory cytokine (interleukin -6)(six-week)
- Ultrasonic assessment(six-week)
- WHR(six-week)
- SBP/DBP(six-week)
研究者
Mohammadreza Rezaeipour
Asst.Prof.Dr. of sports science
University of Sistan and Baluchestan