Effect of Protocolized De-resuscitation on Endothelial Glycocalyx Degradation Products in Critically Ill Adult Patients with Sepsis: A prospective observational study effect of protocol
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 发起方
- 入组人数
- 70
- 试验地点
- 1
- 主要终点
- to compare serum hyaluronan level before
研究概览
简要总结
In this observation study in 70 adult critically ill adult patients with sepsis/septic shock, who have been advised for protocolized deresuscitation by the treating physician with albumin and furosemide, we will study the effect of deresucitation on endothelial glycocalyx degradation products like serum hyaluronan, syndecan, VE cadherin, bioadrenomedulin as well as renal function parameters and clinical outcome like survival to ICU discharge. Our hypothesis is that, dersusciation will hep to preserve endothelial glycocalyx integrity and will correlate with improvement in organ function.
研究设计
- 研究类型
- Observational
入排标准
- 年龄范围
- 18.00 Year(s) 至 75.00 Year(s)（—）
- 性别
- All
入选标准
- •Critically ill patients with sepsis and septic shock, mechanically ventilated patients with iatrogenic volume overload requiring de-resuscitation.
- •Volume overload will be identified by cumulative positive fluid balance of more than 10 percent body weight and / or by clinical signs of fluid overload like in lungs (chest Xray, lung ultrasound ), venous excess ultrasound grade more than 0, of will be included.
排除标准
- •Refusal to participate
- •Pregnancy or post- partum up to 6 weeks
- •Patients who are requiring vasopressor/ inotrope more than norepinephrine dose of 0.2 micrograms per kg per min or equivalent doses.
- •Hypernatremia more than 155 meq/L
- •Receiving renal replacement therapy
- •Patients with medical conditions like diabetic ketoacidosis, hyperosmolar hyperglycemic states, nontraumatic subarachnoid hemorrhage.
- •Acute cardiogenic shock
- •Known allergy to the drugs used.
结局指标
主要结局
to compare serum hyaluronan level before
时间窗: Day 3
and after ‘protocolized de-resuscitation’ in critically ill mechanically ventilated
时间窗: Day 3
adult patients with iatrogenic volume overload
时间窗: Day 3
次要结局
- 1. To compare syndecan-1, VE- Cadherin, bio- adrenomedullin and heparan(sulphate level before and after ‘protocolized de-resuscitation’.)
研究者
Dr Sulagna Bhattacharjee
AIIMS, New Delhi