Clinical Characteristics and Prognostic Factors of Large Cell Neuroendocrine Carcinoma of the Cervix: A Multicenter, Bidirectional Cohort Study
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 发起方
- Lili
- 入组人数
- 200
- 主要终点
- Overall Survival
研究概览
简要总结
Cervical large cell neuroendocrine carcinoma (LCNEC) exhibits highly aggressive biological behavior, including strong invasiveness, a high propensity for metastasis, drug resistance, and poor prognosis, necessitating heightened clinical and pathological awareness. This study aims to summarize the clinical characteristics of LCNEC and analyze various prognostic factors to enhance understanding and vigilance toward this disease. Combined with precise pathological diagnosis, improving diagnostic accuracy is crucial for formulating treatment strategies and assessing patient prognosis.
详细描述
This study will collect the complete medical records of patients with cervical large cell neuroendocrine carcinoma registered in the participating tertiary hospitals, and will prospectively collect the medical records of patients diagnosed with cervical large cell carcinoma. The data to be collected includes:
- Patient demographics (age, place of origin, occupation, etc.)
- Medical history and test results prior to initial treatment:
- Present illness history
- Tumor marker levels
- Pelvic ultrasound
- Whole abdomen CT/MRI
- PET-CT
- Surgical treatment details (date of surgery, surgical approach)
- Pathological examination results
- Administration of neoadjuvant chemotherapy and/or radiotherapy
- Detailed records of all treatment courses and their efficacy (including chemotherapeutic agents, radiotherapy doses, number of cycles, etc.)
- Results from follow-up examinations and imaging studies
- Recurrence status and, if applicable, time to recurrence
- Survival status and, if applicable, date of death For the retrospective cohort, follow-up will be completed within one month after enrollment to document current survival status and recurrence. For the prospective cohort, annual follow-ups will be conducted to record current survival status and recurrence.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Other
入排标准
- 性别
- Female
- 接受健康志愿者
- 否
入选标准
- •The diagnosis of cervical large cell neuroendocrine carcinoma (LCNEC) was confirmed by histopathological examination, meeting both clinical and histological criteria. The tumor exhibited characteristic features, including large cells with abundant cytoplasm, vesicular nuclei with prominent nucleoli, and a high mitotic rate (>10 mitoses/10 HPFs). The growth patterns were predominantly insular, trabecular, or solid, often accompanied by peripheral palisading or rosette formation, along with focal tumor necrosis.
排除标准
- •Mixed cervical LCNEC histology, cases with missing follow-up, or patients lost to contact.
结局指标
主要结局
Overall Survival
时间窗: One month post-enrollment completion and then annual follow-up
Disease Recurrence
时间窗: One month post-enrollment completion and then annual follow-up
次要结局
未报告次要终点