Optimisation of Neonatal Ventilation: Congenital Diaphragmatic Hernia - Determining the Appropriate Level of Volume Guarantee
试验速览
- 阶段
- 不适用
- 入组人数
- 18
- 试验地点
- 2
- 主要终点
- Change in Pressure Time Product of the diaphragm (PTPdi) at different levels of targetted tidal volume
研究概览
简要总结
To determine the appropriate volume (size) of ventilator breath during volume-targetted ventilation for infants born with congenital diaphragmatic hernia.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- — 至 6 Months（Child）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Congenital diaphragmatic hernia - post-operative Mechanically ventilated Born at >34/40
排除标准
- •neuromuscular blockade contraindications to NG/OG tube insertion
研究组 & 干预措施
4, 5, 6ml/kg targetted tidal volume
Randomised to receive TTV at 4ml/kg, 5ml/kg, 6ml/kg. Measurement of PTPdi
干预措施: Measurement of PTPdi (Device)
4, 5, 6ml/kg targetted tidal volume
Randomised to receive TTV at 4ml/kg, 5ml/kg, 6ml/kg. Measurement of PTPdi
干预措施: TTV at 4ml/kg (Device)
4, 5, 6ml/kg targetted tidal volume
Randomised to receive TTV at 4ml/kg, 5ml/kg, 6ml/kg. Measurement of PTPdi
干预措施: TTV at 5ml/kg (Device)
4, 5, 6ml/kg targetted tidal volume
Randomised to receive TTV at 4ml/kg, 5ml/kg, 6ml/kg. Measurement of PTPdi
干预措施: TTV at 6ml/kg (Device)
4, 6, 5ml/kg targetted tidal volume
Randomised to receive TTV at 4ml/kg, 6ml/kg, 5ml/kg. Measurement of PTPdi
干预措施: Measurement of PTPdi (Device)
4, 6, 5ml/kg targetted tidal volume
Randomised to receive TTV at 4ml/kg, 6ml/kg, 5ml/kg. Measurement of PTPdi
干预措施: TTV at 4ml/kg (Device)
4, 6, 5ml/kg targetted tidal volume
Randomised to receive TTV at 4ml/kg, 6ml/kg, 5ml/kg. Measurement of PTPdi
干预措施: TTV at 5ml/kg (Device)
4, 6, 5ml/kg targetted tidal volume
Randomised to receive TTV at 4ml/kg, 6ml/kg, 5ml/kg. Measurement of PTPdi
干预措施: TTV at 6ml/kg (Device)
5, 4, 6ml/kg targetted tidal volume
Randomised to receive TTV at 5ml/kg, 4ml/kg, 6ml/kg. Measurement of PTPdi
干预措施: Measurement of PTPdi (Device)
5, 4, 6ml/kg targetted tidal volume
Randomised to receive TTV at 5ml/kg, 4ml/kg, 6ml/kg. Measurement of PTPdi
干预措施: TTV at 4ml/kg (Device)
5, 4, 6ml/kg targetted tidal volume
Randomised to receive TTV at 5ml/kg, 4ml/kg, 6ml/kg. Measurement of PTPdi
干预措施: TTV at 5ml/kg (Device)
5, 4, 6ml/kg targetted tidal volume
Randomised to receive TTV at 5ml/kg, 4ml/kg, 6ml/kg. Measurement of PTPdi
干预措施: TTV at 6ml/kg (Device)
5, 6, 4ml/kg targetted tidal volume
Randomised to receive TTV at 5ml/kg, 6ml/kg,4ml/kg. Measurement of PTPdi
干预措施: Measurement of PTPdi (Device)
5, 6, 4ml/kg targetted tidal volume
Randomised to receive TTV at 5ml/kg, 6ml/kg,4ml/kg. Measurement of PTPdi
干预措施: TTV at 4ml/kg (Device)
5, 6, 4ml/kg targetted tidal volume
Randomised to receive TTV at 5ml/kg, 6ml/kg,4ml/kg. Measurement of PTPdi
干预措施: TTV at 5ml/kg (Device)
5, 6, 4ml/kg targetted tidal volume
Randomised to receive TTV at 5ml/kg, 6ml/kg,4ml/kg. Measurement of PTPdi
干预措施: TTV at 6ml/kg (Device)
6, 5, 4ml/kg targetted tidal volume
Randomised to receive TTV at 6ml/kg, 5ml/kg, 4ml/kg. Measurement of PTPdi
干预措施: Measurement of PTPdi (Device)
6, 5, 4ml/kg targetted tidal volume
Randomised to receive TTV at 6ml/kg, 5ml/kg, 4ml/kg. Measurement of PTPdi
干预措施: TTV at 4ml/kg (Device)
6, 5, 4ml/kg targetted tidal volume
Randomised to receive TTV at 6ml/kg, 5ml/kg, 4ml/kg. Measurement of PTPdi
干预措施: TTV at 5ml/kg (Device)
6, 5, 4ml/kg targetted tidal volume
Randomised to receive TTV at 6ml/kg, 5ml/kg, 4ml/kg. Measurement of PTPdi
干预措施: TTV at 6ml/kg (Device)
6, 4, 5ml/kg targetted tidal volume
Randomised to receive TTV at 6ml/kg, 4ml/kg, 5ml/kg. Measurement of PTPdi
干预措施: Measurement of PTPdi (Device)
6, 4, 5ml/kg targetted tidal volume
Randomised to receive TTV at 6ml/kg, 4ml/kg, 5ml/kg. Measurement of PTPdi
干预措施: TTV at 4ml/kg (Device)
6, 4, 5ml/kg targetted tidal volume
Randomised to receive TTV at 6ml/kg, 4ml/kg, 5ml/kg. Measurement of PTPdi
干预措施: TTV at 5ml/kg (Device)
6, 4, 5ml/kg targetted tidal volume
Randomised to receive TTV at 6ml/kg, 4ml/kg, 5ml/kg. Measurement of PTPdi
干预措施: TTV at 6ml/kg (Device)
结局指标
主要结局
Change in Pressure Time Product of the diaphragm (PTPdi) at different levels of targetted tidal volume
时间窗: 3 hours
PTPdi will be measured at each level of tidal volume. The outcome measure is the change in PTPdi.
次要结局
未报告次要终点