跳至主要内容
临床试验/NCT06326372
NCT06326372已完成不适用

The Effect of Intraoperative Hyperoxemia on Postoperative Delirium in Geriatric Patients and the Preventive Role of Oxygen Reserve Index"

Tepecik Training and Research Hospital1 个研究点 分布在 1 个国家目标入组 114 人开始时间: 2023年10月1日最近更新:
适应症

试验速览

阶段
不适用
状态
已完成
发起方
入组人数
114
试验地点
1
主要终点
Correlation of FiO2 and ORi value

研究概览

简要总结

Oxygen therapy is the most common treatment modality for patients with hypoxemia, but target values for normoxemia are not clearly defined. Therefore, iatrogenic hyperoxemia is a very common situation. Even though there are many side effects reported related to hyperoxemia and hyperoxemia is shown to be related to worse outcome than expected; clinicians still observe hyperoxemia frequently.

Oxygen reserve index (ORi™) (Masimo Corp., Irvine, USA) can guide clinicians in detection of hyperoxia. ORi is a parameter which can evaluate partial pressure of oxygen (PaO2) rating from 0 to 1. There are growing evidences in ORi that it might be helpful to reduce hyperoxia in general anesthesia. Continuous ORi monitoring can be used for detecting and preventing hyperoxia. The ability to perform FiO2 titration with ORi may be an appropriate monitoring management to prevent the harmful effects of hyperoxia.In this study, in patients who underwent major abdominal surgery; It was aimed to investigate the effectiveness of ORi-guided FiO2 titration in preventing hyperoxia.

详细描述

The definition of elderly by the World Health Organization is individuals aged 65 and older. As the average life expectancy continues to increase, the number of surgical procedures performed in the geriatric population is also increasing.

Postoperative delirium is a complication that occurs after surgery and is characterized by sudden-onset confusion, fluctuating mental status, and attention deficits. Its incidence increases in elderly patients and is higher in those with pre-existing mild cognitive impairment. The etiology encompasses multiple factors such as age, presence of additional comorbidities, metabolic disorders, hypoxia, polypharmacy, pain, hypothermia, and may be associated with the depth of anesthesia during surgery.

Early recognition and prevention of delirium will become more prominent in the future due to reduced hospitalization durations, postoperative complications, and mortality rates.

Various methods are available to detect hyperoxemia during surgery. Hyperoxemia can be detected using noninvasive finger pulse oximetry with the oxygen reserve index parameter. Oxygen levels can be noninvasively assessed during operations using routine oxygen saturation and oxygen reserve index measurements.

Delirium can be evaluated in both intensive care and ward patients. The gold standard for diagnosis is the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5) criteria. DSM-5 criteria require psychiatric evaluation and are conducted by someone with psychiatric training. Additionally, the Confusion Assessment Method (CAM) is used for diagnosis and can be evaluated as CAM-ICU for intubated patients in intensive care units.

研究设计

研究类型
Observational
观察模型
Cohort
时间视角
Prospective

入排标准

年龄范围
65 Years 至 —(Older Adult)
性别
All
接受健康志愿者

入选标准

  • Patients aged 65 and older
  • Patients expected to have surgery lasting more than 2 hours
  • Patients with ASA (American Society of Anesthesiologists) classification 1-2-3-4
  • Patients planned to have at least 2 days of postoperative hospitalization

排除标准

  • Patients with preoperative central nervous system disorders or dementia
  • Patients with MMSE (Mini-Mental State Examination) scores of 23 or below
  • Patients unable to communicate
  • Emergency surgeries
  • Patients who refuse to participate in the study
  • Patients using high-dose vasopressors
  • Patients with peripheral hypoperfusion
  • Hemodynamically unstable patients

结局指标

主要结局

Correlation of FiO2 and ORi value

时间窗: Until the surgery is over

Correlation of FiO2 value and ORi value. FiO2 adjusted until ORi reaches to zero and %95\<oxygen saturation≤%98

Correlation of ORi and Delirium

时间窗: Up to 48 hours

Correlation of ORİ and SpO2 values with delirium measured by CAM and CAM-ICU

次要结局

  • Correlation of FiO2 and delirium(first 10 th minutes after entubation and every 10 minutes until surgery is over)

研究者

发起方
Tepecik Training and Research Hospital
申办方类型
Other
责任方
Principal Investigator
主要研究者

Aykut Saritas

associated professor

Tepecik Training and Research Hospital

研究点 (1)

Loading locations...

相似试验

The Effect of Intraoperative Hyperoxemia on... | 临床试验