NCT01713829已完成不适用
Cranberry Consumption Improves γδ T Cell Function
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 52
- 试验地点
- 2
- 主要终点
- Change in Immune Cell Function
研究概览
简要总结
The purpose of this study is to determine the extent to which consuming a cranberry beverage modifies immune function, specifically related to γδ T cells and other innate immune cells. It is hypothesized that cranberry components will interact with immune cells to activate signaling pathways that enhance cell function. Enhanced immune cell function should result in reduced number, duration, and severity of cold and flu symptoms.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Basic Science
- 盲法
- Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 21 Years 至 35 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •between 21 and 35 years of age and in good health
- •have a BMI between 18.5 and 29.9
- •willing to consume the study beverage for 12 weeks
- •willing to have a small amount of blood drawn two times
- •willing to stop consuming tea and immune-enhancing dietary supplements (e.g. antioxidant-, probiotic-, or flavonoid-containing supplements, fish oil, and Echinacea) before and during the 12 weeks of the study
- •willing to consume no more than 7 servings of fruits and vegetables a day
- •willing to limit your alcohol consumption to no more than 14 glasses a week
- •willing to limit your yogurt consumption to no more than one 8oz. serving per day
排除标准
- •have food allergies
- •have hypertension
- •taking non-steroidal anti-inflammatory drugs on a chronic basis, antibiotics, or immunosuppressive drugs
- •sensitive to aspirin or prone to kidney stones
- •current smoker
- •pregnant, lactating, or on hormone therapy, except for birth control pills
结局指标
主要结局
Change in Immune Cell Function
时间窗: Measured at baseline and 6 weeks
* Change in leukocyte phenotype * Change in the ability of the natural killer and/or γδ T cells to proliferate when cultured ex vivo * Change in peripheral blood mononuclear cell cytokine and chemokine production in response to mitogens
次要结局
- Cold and Flu Symptoms(12 weeks)
研究者
研究点 (2)
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