A Multi-omics Breast Cancer Distant Metastasis Prediction Model Empowered by Artificial Intelligence and Its Clinical Translation Research
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 发起方
- 入组人数
- 2,000
- 试验地点
- 1
- 主要终点
- Metastasis-Free Survival
研究概览
简要总结
Breast cancer is one of the most common malignancies in women worldwide, and distant metastasis is the main cause of poor prognosis and death. This project aims to construct a precision prediction system based on multi-omics (digital pathology, immunohistochemistry, proteomics, gene sequencing) and artificial intelligence to predict distant and organ-specific metastasis (bone, lung, liver, brain) in breast cancer, analyze its mechanisms, and provide new solutions for precision medicine.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 性别
- Female
- 接受健康志愿者
- 否
入选标准
- •Female patients pathologically diagnosed with breast cancer at our hospital or participating centers between January 1, 2000, and December 30,
- •Must meet one of the following: 1) Initially diagnosed with breast cancer at our hospital, has developed distant metastasis (liver, bone, lung, or brain), and has a biopsy or surgical specimen from the metastatic site stored at our hospital, with complete clinical information available. 2) Primary tumor specimen is not at our hospital, but a biopsy or surgical specimen from a distant metastatic site (liver, bone, lung, brain) is stored at our hospital.
排除标准
- •Concomitant metastatic malignancy from another primary cancer.
- •Incomplete clinical information.
研究组 & 干预措施
Group 1
Metastatic Risk Stratification (High/Medium/Low Risk)
Group 2
Organ-Specific Metastasis (Bone/Lung/Liver/Brain)
Group 3
Non-Metastatic Control Group
结局指标
主要结局
Metastasis-Free Survival
时间窗: From diagnosis up to December 30, 2028
Time from initial breast cancer diagnosis to the occurrence of distant metastasis.
次要结局
- Performance of Prediction Models(At the end of the study (December 2028))
研究者
Jian Huang
Head of Breast Surgery Department
Second Affiliated Hospital, School of Medicine, Zhejiang University