Immunohistochemical expression of bcl2 and Ki-67 in thyroid neoplasms.

The thyroid gland arises as a median outgrowth from the floor of pharynx near the

base of tongue. Thyroid neoplasms include a wide range of lesions with various histopathologic

characteristics.The benign neoplasms are mainly adenomas which are typically discrete,

solitary masses, derived from follicular epithelium, and hence they are also known as

follicular adenomas (FA). Malignant thyroid neoplasms are mainly carcinomas, accounting

for about 1.5% of all cancers. Although these neoplasms are diagnosed using precise criteria,

it is challenging to distinguish between some neoplasms, such as follicular adenoma and

follicular carcinoma. Hence, additional diagnostic tests that can help with this differentiation

would be very beneficial in the clinical scenario. Thyroid cancer is the most common endocrine cancer today. Its incidence has

increased all over the world in the last three decades. An accurate diagnosis of thyroid

neoplasm is therefore crucial as it has a major impact on the treatment modality as well as

the patient’s prognosis. This study is being done to determine expression of bcl2 and Ki-67

in thyroid neoplasms and to correlate these with histopathological finding.