Evaluation and Comparison of Malnutrition and Sarcopenia Risk Using PG-SGA, MUST, Nutriscore, and GLIM Criteria in Cancer Patients Undergoing Chemotherapy
试验速览
- 阶段
- 不适用
- 状态
- 进行中（未招募）
- 发起方
- 入组人数
- 200
- 试验地点
- 1
- 主要终点
- PG-SGA short form values
研究概览
简要总结
The study will include approximately 150 adult outpatients diagnosed with solid tumors who are currently receiving chemotherapy. Both early and advanced stage patients of any sex aged 18 and older will be included, provided they are clinically stable and able to participate in the assessments.
详细描述
Background: Malnutrition and sarcopenia are prevalent and clinically significant conditions in cancer patients receiving chemotherapy. Accurate nutritional screening and early diagnosis of sarcopenia are critical for improving treatment outcomes and quality of life. Several screening tools are used for nutritional risk assessment in oncology, including PG-SGA, MUST, Nutriscore, and the recently proposed GLIM criteria.
Objective
This cross-sectional study aims to evaluate the risk of malnutrition and sarcopenia in solid tumor outpatients receiving chemotherapy. It compares the effectiveness and correlation of PG-SGA, MUST, Nutriscore, and GLIM criteria, and investigates their association with sarcopenia, measured via handgrip strength and CT-based skeletal muscle index at the L3 level.
Methods: Approximately 150 adult cancer patients receiving active outpatient chemotherapy will be assessed. Nutritional status will be evaluated using PG-SGA, MUST, Nutriscore, and GLIM. Sarcopenia will be determined via handgrip strength testing and analysis of CT images. Charlson Comorbidity Index will be used to assess comorbidity burden.
研究设计
- 研究类型
- Observational
- 观察模型
- Other
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Age ≥ 18 years
- •Diagnosed with a solid tumor (e.g., breast, lung, GI, gynecologic cancers)
- •Receiving active outpatient chemotherapy
- •Recent abdominal CT scan within the last 3 months or planned
- •Provided written informed consent
- •Physically and mentally able to complete study procedures
排除标准
- •Declined or unable to give informed consent
- •Cognitive impairment or mental status preventing participation
- •Neuromuscular diseases affecting muscle mass (e.g., myopathy, MND, severe neuropathy)
- •Inadequate CT image quality for L3 analysis
- •Acute infection or illness within the past month
- •Upper limb deformity or severe pain preventing handgrip testing
- •Incomplete assessments or withdrawal of consent during the study
结局指标
主要结局
PG-SGA short form values
时间窗: From enrollment to 6 month
Nutriscore
时间窗: From enrollment to 6 month
次要结局
未报告次要终点
研究者
Şeyma Eroğlu
Oncology Fellowship Dr.
Çanakkale Onsekiz Mart University