NCT02335996已完成不适用
Impact Hypercortisolism on Adipose Epicardial and on Myocardial Function
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 43
- 试验地点
- 2
- 主要终点
- Assess cardiovascular risk by a blood complete lipid profile
研究概览
简要总结
Identifying hypercortisolism patients at risk for cardio-vascular events despite biological cure, and determine which patients should be particularly followed. Hypercortisolic patients represent an ideal in vivo model to determine the interactions between glucocorticoids and ectopic fat development.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Parallel
- 主要目的
- Diagnostic
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Major, male or female
- •Introducing an active or healed hypercortisolism caused by Cushing's disease
- •signed informed consent.
排除标准
- •Elderly patients under 18 years
- •Pregnant or lactating women
- •Previous history of myocardial infarction
- •Antecedent congenital cardiomyopathy
- •Adrenocorticotropic hormone-independent Hyperadrenocorticism
- •Hyperadrenocorticism by ectopic Adrenocorticotropic hormone secretion
- •Treatment with corticosteroids or insulin
- •Specific contraindication to the achievement of Nuclear Magnetic Resonance (metal heart valves, pacemakers, metallic foreign body, claustrophobia)
- •Persons deprived of liberty
- •Persons not affiliated to a social security scheme
- •People unable to give their consent in writing (in person or with the assistance of a third party).
结局指标
主要结局
Assess cardiovascular risk by a blood complete lipid profile
时间窗: 36 months
measuring the volume of epicardial adipose tissue, as measured by MRI to 3 Tesla.
时间窗: 36 months
Assess insulin resistance by the blood sugar and insulin levels
时间窗: 36 months
次要结局
- Assess cardiovascular risk by the blood leptin, adiponectin and omentin plasma level(36 months)
- Assess insulin resistance by the blood leptin, adiponectin and omentin plasma level(36 months)
研究者
研究点 (2)
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