Blood and Muscle Responses to Sodium Bicarbonate Supplementation and Subsequent Exercise Performance
试验速览
- 阶段
- 不适用
- 入组人数
- 15
- 主要终点
- H+ transporter activity
研究概览
简要总结
The aim of this study is to evaluate the changes in activity of transporters of H+ (monocarboxylate transporters; MCT1, MCT4, NHE) following sodium bicarbonate supplementation and subsequent exercise performance. Fifteen healthy men (age 18-35 years) will be invited to attend the laboratory on five separate visits to a randomized, double-blind, placebo-controlled study. Participants will be supplemented with a 0.3 g/kg dose of sodium bicarbonate or placebo (Analytical Pharmacy, Brazil) in opaque gelatin capsules. One hour after supplementation they will perform a 1-km time trial and every 10 minutes a blood sample will be collected. A muscle biopsy will be taken prior to supplementation, immediately prior to exercise, and immediately post-exercise. A questionnaire will be also used to evaluate the side-effects associated with sodium bicarbonate supplementation. Muscle and blood samples will be analysed for acidity and H+ and muscle samples will be analysed for H+ transporters (MCT1, MCT4, NHE).
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Other
- 盲法
- Triple (Participant, Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 35 Years（Adult）
- 性别
- Male
- 接受健康志愿者
- 是
入选标准
- •Healthy males
排除标准
- •Chronic disease
- •Prior or current use of steroids
- •Use of creatine in the last 6 months
- •Use of beta-alanine in the last 6 months
研究组 & 干预措施
Placebo
Individuals will ingest 0.3 g/kg maltodextrin before undergoing exercise
干预措施: Maltodextrin (Dietary Supplement)
Sodium bicarbonate
0.3 g∙kg-1body mass of sodium bicarbonate
干预措施: Sodium bicarbonate (Dietary Supplement)
结局指标
主要结局
H+ transporter activity
时间窗: 5 minutes Post-exercise
Change in activity of transporters related to H+
次要结局
- Exercise performance(1 hour Post-supplementation)
研究者
Bruno Gualano
Professor
University of Sao Paulo