Quantitative Net Water Uptake as a Predictor of Functional Outcomes After Intravenous Thrombolysis in Acute Ischemic Stroke International Multicenter Observational Retrospective Study
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 发起方
- 入组人数
- 200
- 试验地点
- 1
- 主要终点
- Functional independence
研究概览
简要总结
While the effectiveness of intravenous thrombolysis (IVT) decreases over time, patients show considerable variability in how quickly their ischemic core progresses. Quantitative net water uptake (NWU) has emerged as a biomarker indicating blood-brain barrier disruption and may better reflect the "tissue clock" than time alone. Low NWU is associated with favorable outcomes, whereas high NWU predicts poor outcomes and futile recanalization. The study aims to determine whether NWU measured on initial non-contrast CT is a treatment effect modifier for the IVT therapy.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Acute ischemic stroke treated with intravenous thrombolysis
- •Imaging with non-contrast cranial CT on admission
- •Follow-up imaging with non-contrast cranial CT or MRI 12-24 hours after IVT
- •Final Infarct volume > 5ml
- •ASPECTS available
排除标准
- •Known use of oral anticoagulation (OAC) on admission
- •Preexisting ischemic infarction on admission non-contrast cranial CT
- •Patients with large vessel occlusion AIS who underwent mechanical thrombectomy
- •Low imaging quality precluding radiological measurements
- •Severe white matter lesions precluding radiological measurements
- •No ASPECTS
研究组 & 干预措施
patients with ischemic stroke receiving IVT
干预措施: No Interventions (Other)
结局指标
主要结局
Functional independence
时间窗: at 90 days
modified Rankin Scale of 0-1
Number of participants with functional independence (modified Rankin Scale score 0-1)
时间窗: at 90 days
Functional independence defined as a modified Rankin Scale (mRS) score of 0-1 assessed at 90 days.
次要结局
- Intracerebral hemorrhage(at 24 hours)
- Mortality(at 90 days)
- Symptomatic intracerebral hemorrhage(at 24 hours)
- Number of participants with symptomatic intracerebral hemorrhage(at 24 hours)
- Number of participants with intracerebral hemorrhage on follow-up brain imaging(at 24 hours)