Optimization of Perioperative Analgesia with Erector Spinae Plane Block During Major Abdominal Surgeries in Patients with Impaired Liver Function
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 50
- 试验地点
- 1
- 主要终点
- Pain reduction postoperative
研究概览
简要总结
The goal of this clinical trial is to learn if ESP block is safe and effective for perioperative analgesia in patients undergoing liver transplant. The main question it aims to answer are Is ESP block safe and has a minimum side effects, like hematoma? Is it effective for perioperative analgesia? Researchers will compare the results to a group of patients who underwent liver transplants without any regional anaesthesia techniques.
Participants will receive bilateral thoracic ESP block on the day of the transplantation with a subsequent bilateral catheterization.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •impaired liver function - cirrhosis or chronic liver disease with the development of hypocoagulation (APTT > 35 sec, INR > 1.5), thrombocytopenia, patients requiring major abdominal surgery, age > 18 years, written consent to participate in the study was obtained
排除标准
- •Platelet count <50x109, failed ESP catheterization unilateral or bilateral, failed epidural anesthesia attempt, history of allergy or hypersensitivity to local anesthetics, hepatopulmonary syndrome, patients on mechanical ventilation before surgery, patients on CRRT before surgery, refusal to participate in the study
结局指标
主要结局
Pain reduction postoperative
时间窗: from enrollment to the 2nd postoperative day
Pain assessment with scores
Opioid reduction intraoperatively
时间窗: from enrollment to the end of the operation
The amount of intraoperative fentanyl
Need for opioids postoperatively
时间窗: from enrollment to the 2nd postoperative day
Need for opioids postoperatively
次要结局
未报告次要终点
研究者
Nazarii Mysynchuk
MD
Bogomolets National Medical University