The Effect of Preoperative Anxiety With Depth of Anesthesia During Oocyte Retrieval on IVF Success
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 131
- 主要终点
- Changes in perioperative Monitoring brain function were measured
研究概览
简要总结
This study evaluated the effects of preoperative anxiety and dosage of anesthesia on IVF success. Half of participants according to the recorded Beck's Anxiety Inventory (BAI) score: a low-anxiety group, while the other half high-anxiety group.
详细描述
Anxiety is common among women hospitalized for oocyte retrieval. Infertility is usually accompanied by psychological and behavioral changes and can result in preoperative anxiety. Sometimes, preoperative anxiety can be serious. Furthermore, in the absence of premedication for oocyte retrieval, severe degrees of anxiety may occur. Anxiety effects the total consumption of analgesic and anesthetic drugs intraoperatively and has a negative impact on recovery from anesthesia. In addition, the negative effect of anesthetic agents used on fertilization and embryo quality during in vitro fertilization (IVF) has been discussed. However, the impact of any of them on fertilization and embryo quality has not been clearly determined to date. Studies have reported different results regarding the negative effects of anesthetic agents on embryo development and fertilization.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Double (Participant, Investigator)
入排标准
- 年龄范围
- 25 Years 至 43 Years（Adult）
- 性别
- Female
- 接受健康志愿者
- 是
入选标准
- •oocyte retrieval under sedation
- •25 and 43 years of age
- •American Society of Anesthesiologists physical status I-II
排除标准
- •history of psychiatric illness
- •secondary infertility can be surgically corrected
- •not able to communicate well in the native language
- •those women who necessitated general anesthesia
研究组 & 干预措施
Monitoring brain function-low-anxiety
Anxiety has determined a cutoff score of 17. Patients were divided into two groups according to the recorded BAI score: a low-anxiety group and a high-anxiety group.The monitoring brain function values were recorded at baseline, 5 minutes, 15 minutes, and after anesthesia. Propofol was performed by ventilation with face mask. Monitoring brain function was keep value between 40 and 60.
干预措施: Monitoring brain function (Device)
Monitoring brain function-low-anxiety
Anxiety has determined a cutoff score of 17. Patients were divided into two groups according to the recorded BAI score: a low-anxiety group and a high-anxiety group.The monitoring brain function values were recorded at baseline, 5 minutes, 15 minutes, and after anesthesia. Propofol was performed by ventilation with face mask. Monitoring brain function was keep value between 40 and 60.
干预措施: propofol (Drug)
monitoring brain function-high-anxiety
Anxiety has determined a cutoff score of 17. Patients were divided into two groups according to the recorded BAI score: a low-anxiety group and a high-anxiety group.The monitoring brain function values were recorded at baseline, 5 minutes, 15 minutes, and after anesthesia. Propofol was performed by ventilation with face mask. Monitoring brain function was keep value between 40 and 60.
干预措施: Monitoring brain function (Device)
monitoring brain function-high-anxiety
Anxiety has determined a cutoff score of 17. Patients were divided into two groups according to the recorded BAI score: a low-anxiety group and a high-anxiety group.The monitoring brain function values were recorded at baseline, 5 minutes, 15 minutes, and after anesthesia. Propofol was performed by ventilation with face mask. Monitoring brain function was keep value between 40 and 60.
干预措施: propofol (Drug)
结局指标
主要结局
Changes in perioperative Monitoring brain function were measured
时间窗: Preoperative, intraoperative and postoperative first minute
Monitoring brain function was assessed Change from baseline at preoperatively, intraoperative 5th and 15th minutes and after anesthesia
次要结局
- pregnancy rate(10 days)
研究者
Sevtap Hekimoglu Sahin
Clinical Professor
Trakya University