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临床试验/NCT02068755
NCT02068755已完成不适用

The Use of Blood Products in Patients Undergoing Cardiac Surgery

University of Turku0 个研究点目标入组 31,000 人开始时间: 2002年1月最近更新:
适应症

试验速览

阶段
不适用
状态
已完成
入组人数
31,000
主要终点
Red blood cell infusions

研究概览

简要总结

Blood transfusion is a common procedure essential for the treatment of patients undergoing cardiac surgery. Inappropriate transfusions, however, not only incur needless healthcare costs, but increase unnecessary risks due to transfusion reactions and infectious and immunomodulative causes. Safe and appropriate patient care requires evaluated blood component prescription practices.

Practically all patients undergoing cardiac surgery in Finland have a blood product booking from the Finnish Red Cross Blood Service. This registry contains large volumes of transfusion-related information on all Finnish patients undergoing cardiac surgery in Finnish centers. Participating hospitals were scattered to all geographical areas in Finland and concentrated to the most populated regions.

Data on the blood product use, laboratory findings one month pre-operatively and 12 months post-operatively were available.

Finnish hospitals have been required to provide information on hospital visits for the Finnish National Research and Development Centre for Welfare and Health for healthcare planning purposes. We used in part the original data sent by hospitals to the Finnish Hospital Discharge Register (FHDR).

详细描述

Registry includes

  • >21 000 patients who underwent coronary bypass,
  • >4500 patients with aortic valve replacement,
  • >4000 mitral valve operation.

研究设计

研究类型
Observational
观察模型
Cohort
时间视角
Prospective

入排标准

年龄范围
18 Years 至 —(Adult, Older Adult)
性别
All
接受健康志愿者

入选标准

  • Cardiac surgery performed in Finnish University and Central hospitals
  • Blood product booking for surgery

排除标准

  • 未提供

结局指标

主要结局

Red blood cell infusions

时间窗: 12 months

Platelet infusion

时间窗: 12 months

Fresh frozen plasma

时间窗: 12 months

Octaplas

时间窗: 12 months

次要结局

  • TIA/stroke/arterial embolism(12)
  • re-operation due to bleeding(12 months)
  • myocardial infarction(12 months)
  • All cause mortality(12 months)

研究者

申办方类型
Other
责任方
Principal Investigator
主要研究者

Dr. Pirjo Mustonen, MD, PhD

Professor

University of Turku

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