The Use of Blood Products in Patients Undergoing Cardiac Surgery
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 31,000
- 主要终点
- Red blood cell infusions
研究概览
简要总结
Blood transfusion is a common procedure essential for the treatment of patients undergoing cardiac surgery. Inappropriate transfusions, however, not only incur needless healthcare costs, but increase unnecessary risks due to transfusion reactions and infectious and immunomodulative causes. Safe and appropriate patient care requires evaluated blood component prescription practices.
Practically all patients undergoing cardiac surgery in Finland have a blood product booking from the Finnish Red Cross Blood Service. This registry contains large volumes of transfusion-related information on all Finnish patients undergoing cardiac surgery in Finnish centers. Participating hospitals were scattered to all geographical areas in Finland and concentrated to the most populated regions.
Data on the blood product use, laboratory findings one month pre-operatively and 12 months post-operatively were available.
Finnish hospitals have been required to provide information on hospital visits for the Finnish National Research and Development Centre for Welfare and Health for healthcare planning purposes. We used in part the original data sent by hospitals to the Finnish Hospital Discharge Register (FHDR).
详细描述
Registry includes
- >21 000 patients who underwent coronary bypass,
- >4500 patients with aortic valve replacement,
- >4000 mitral valve operation.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —(Adult, Older Adult)
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Cardiac surgery performed in Finnish University and Central hospitals
- •Blood product booking for surgery
排除标准
- 未提供
结局指标
主要结局
Red blood cell infusions
时间窗: 12 months
Platelet infusion
时间窗: 12 months
Fresh frozen plasma
时间窗: 12 months
Octaplas
时间窗: 12 months
次要结局
- TIA/stroke/arterial embolism(12)
- re-operation due to bleeding(12 months)
- myocardial infarction(12 months)
- All cause mortality(12 months)
研究者
Dr. Pirjo Mustonen, MD, PhD
Professor
University of Turku
