Dose Response Relationship between Near Infrared (NIR) Light Stimulation and Functional Brain Activity

Fogarty International Center of National Institutes of Health0 个研究点目标入组 0 人开始时间: 待定最近更新: 2021年11月24日

试验速览

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•1. Able to provide informed consent
•2. Willingness to be randomized to Sham or Real stimulation groups
•3. Willingness to undergo two brain MRI-MRS scans and commit time necessary for the study
•4. Lives independently with no impairment in social or occupational function
•At least 8th grade education
•Scores > 25 on Hindi Mental State Examination
•On stable doses of major medications for last 3 months
•Score < 14 on the Beck Depression Inventory-II

•1. Unstable and uncontrolled medical conditions; diagnosis of cancer
•2. Previous major strokes or other known significant brain abnormalities, diseases, or disorders affecting cognition
•3. Evidence of mild cognitive impairment or potential dementia, meeting DSM-V criteria for Major or Minor Neurocognitive Disorder
•4. Current or past history of major psychiatric disturbance
•Use of antipsychotics, sedatives, or other medications with significant anticholinergic properties (due to potential influence on memory)
•Use of photo-sensitive medications within 15 days of the study intervention
•Presence of claustrophobia
•Implants such as pacemakers, heart vales, brain aneurysm clips, orthodontics, non-removable body jewelry, or shrapnel containing ferromagnetic metal

发起方

Fogarty International Center of National Institutes of Health