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临床试验/NCT04336865
NCT04336865Unknown不适用

Effect of Hormonal Contraception on Lower Urinary Tract Symptoms& Sexual Function

Assiut University1 个研究点 分布在 1 个国家目标入组 177 人开始时间: 2020年4月15日最近更新:
适应症

试验速览

阶段
不适用
入组人数
177
试验地点
1
主要终点
Arabic female sexual function index

研究概览

简要总结

Effect of hormonal contraception on lower urinary tract symptoms& sexual function

详细描述

It is generally accepted that female sex hormones influence the morphology and physiology of vaginal tissues. Peripheral estrogen affects urogenital connective tissue composition and structure, vaginal blood flow, and thickness of vaginal epithelium. Estrogen and progestagen receptors are also abundantly present in the lower urinary tract, which has the same embryonic origin as the vagina. decline in circulating estrogen levels may result in atrophy of vaginal, urethral and bladder trigonal epithelium, as well as initiate metabolic changes in the subepithelial supportive tissues. This process forms the biological rationale for the common clinical practice of prescribing hormone treatment to menopausal women with lower urinary and genital tract symptoms.

Contrary to widespread belief, the Womens Health Initiative (WHI) randomised trial showed that menopausal hormone therapy with conjugated estrogen alone, or in combination with progestagen, increased the risk of de novo or aggravated urinary incontinence after one year of treatment. In premenopausal women, oral contraception is the most common source of hormone intake but very few studies have endeavored to determine the effects of oral contraception on premenopausal urinary incontinence. The aim of this nationwide cohort study was to assess the influence of contraceptives on the risk for lower urinary tract dysfunction in young female.at is time-related with the beginning of hormonal contraception, health care providers should give information about other methods and try to switch them to a method less associated with sexual dysfunction. However, there are contradictory results between the different studies regarding the association between sexual dysfunction and hormonal contraceptives, so it could be firmly said that additional research is needed.

Meanwhile, it could be said that hormonal contraception has been associated with different alterations in sexual functioning.

To conclude, a multidisciplinary approach to the management of female sexual dysfunction is mandatory, and health care providers should give lifestyle counselling apart from proposing different treatment options. An adequate relationship with the patient, as well as the routine monitoring of possible sexual dysfunction, are essential in addressing these difficulties. Undoubtedly, the best contraceptive is one that fulfills the women's needs with acceptable side effects and agreed with the prescribed

研究设计

研究类型
Observational
观察模型
Case Only
时间视角
Retrospective

入排标准

年龄范围
18 Years 至 45 Years(Adult)
性别
Female
接受健康志愿者
否

入选标准

  • •Women taking hormonal contraception e.g cocs .pops.implanon&.injectable contraception
  • •Women has good regular marital life

排除标准

  • •female has organic urinary dysfunction
  • •female has mental& psycological dysfunction
  • •chronic disease DM.hypertension. chronic renal disease
  • •previous perineal &vaginal correlation surgery
  • •women taking any treatment for urinary tract infection &sexual dysfunction

结局指标

主要结局

Arabic female sexual function index

时间窗: baseline

valid questionnaire that can be used in the Egyptian population. The questionnaire is relatively easy to be understood by lay women and does not contain unacceptably sexually explicit questions, which may pose difficulties for self-rating. ArFSf I is valid and reliable,and it is as good as the original FSFI in assessing female sexual function \&good psychometric tool for sexual dysfunction . Research in the area of female sexuality is not easy and relatively challenging in the Arab world

Bristol female lower urinary tract symptoms questionnaire

时间窗: baseline

it was designed to asses lower urinary tract symptoms in women \& quality of sexual life . it will be translated into arabic language

次要结局

未报告次要终点

研究者

申办方类型
Other
责任方
Principal Investigator
主要研究者

randa habeeb yacoup

resident doctor

Assiut University

研究点 (1)

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