The Role of Galectin-3 in the Pathogenesis and Prediction of Placenta Accreta
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 62
- 试验地点
- 1
- 主要终点
- Galactin 3 level in the blood
研究概览
简要总结
Galectins are a family of carbohydrate-binding proteins that have a high affinity to galactosides, its protein portion is located in the nucleus and the cytoplasm with its carbohydrate recognition domain which has high ability to be glycosylated inside or outside the cell.
They are expressed by vascular endothelium, immune cells (macrophages, neutrophils, and mast cells), uterus, placenta, cardiac muscle, liver, epithelium of the gastrointestinal tract, and many other tissues.
Although some galectins have intracellular functions, the majority of them have extracellular activities, which facilitate their contribution to cell adhesion, cell activation, and inflammation. Galectin-3 (Gal-3) is a unique pentamer of the galectins family and it is involved in both physiological functions; cell growth and differentiation, and pathological conditions; inflammation, fibrosis, and metastasis.
Regarding pregnancy, Gal-3 is proved to participate in angiogenesis, embryo developmental processes, and modulation of maternal immunity.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Crossover
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 20 Years 至 40 Years（Adult）
- 性别
- Female
- 接受健康志愿者
- 否
入选标准
- •Pregnant women between 28-32 weeks.
- •Age between 20-40 years.
- •Singleton pregnancy.
- •Women with suspicion of placenta accreta
- •Cases with mild vaginal bleeding or not having any vaginal bleeding.
排除标准
- •Women are known to have any medical disorders.
- •Patients with known bleeding disorders or on anticoagulant therapy.
- •Patients refuse to participate.
结局指标
主要结局
Galactin 3 level in the blood
时间窗: 6 weeks
measured by ng/ml
次要结局
未报告次要终点
研究者
Mohammed Khairy Ali
Assistant professor
Assiut University