NCT07645391招募中不适用
Targeted Early Detection Program in Men at High Genetic Risk for Prostate Cancer
适应症
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 200
- 试验地点
- 1
研究概览
简要总结
This study evaluates urinary biomarkers and PSA to help determine the best approach to early detection of prostate cancer in patients with an elevated familial risk.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 35 Years 至 70 Years（Adult, Older Adult）
- 性别
- Male
- 接受健康志愿者
- 否
入选标准
- •* Age 35-70 years
- •Capable of providing informed consent
- •Prognosis of > 5 years if affected by another cancer
- •Patients need one to meet at least one of the following high genetic risk categories:
- •Known PCa-related mutations: BRCA 1 and 2, Lynch syndrome, or p53
- •Carrier of mutation in a suspected PCa-related gene: e.g., ATM, PALB2, CHEK2, RAD51D, ATR, NBN, GEN1, RAD51C, MRE11A, BRIP1, FAM175A, HOXB13
- •Obligate carriers of the above mutations (e.g. their sisters/daughters have known mutations)
- •Men with any family history of above mutation
- •Family history of breast, prostate, or ovarian cancer in at least 2 individuals, or in 1 individual diagnosed before age 50
排除标准
- •* Anuria
- •Prior diagnosis or treatment for PCa
- •Failure to provide informed consent
- •Life expectancy < 5 years
研究者
研究点 (1)
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