Multimodal Treatment of Phonological Alexia: Behavioral & fMRI Outcomes
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 5
- 试验地点
- 2
- 主要终点
- Change in Real World Reading Skills
研究概览
简要总结
This study offers 90-120 hours of 1:1 training to improve reading skills in adults who have poor reading skills following a stroke. Specifically, this study is designed to improve skill in sounding out words for reading and spelling. The overall time commitment for participation in this study is approximately 11-30 weeks.
详细描述
The proposed study is a mixed-effects (single-subject ABA repeated-probe and small group elements) design with 90-120 hours of a modified multi-modal treatment of alexia replicated across up to 18 adults with post-stroke phonological alexia. The short-term goals of this research proposal includes the following: 1) determine if a modified multimodal treatment of phonological alexia can improve pseudoword reading skills (providing a basis from which training will also treat real word reading skills), 2) determine if a modified multimodal treatment of phonological alexia can improve real word reading skills, 3) determine how brain lesion extent and location relate to participants' response to treatment, and 4) identify relationships between changes in functional brain activity in specified regions of interest and participants' response to treatment.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Adults with post-stroke reading difficulties (phonological alexia)
- •>3 months post-stroke
- •native English speaker
- •can go in MRI scanner (3 to 6 scans),
- •participate in 90 to 120 free treatment sessions
- •return for 3-month post-treatment follow-up assessment & MRI.
排除标准
- •mental illness
- •degenerative disease, visual or auditory acuity impairment
- •drug abuse
- •English is not first language
- •claustrophobia
- •pregnancy
研究组 & 干预措施
Arm 1
Repeated probes every 8 hours of treatment (1/week)
干预措施: One-on-one treatment of reading difficulties (Behavioral)
结局指标
主要结局
Change in Real World Reading Skills
时间窗: Language testing are conducted two weeks prior to treatment, immediately following end of treatment and 3 months after end of treatment.
Real World Reading Skills was tested using the Woodcock Reading Mastery Test-Revised
次要结局
未报告次要终点