A Pilot Study of the Myocardial Effects of an Endurance Race as Evaluated by Computer Tomography
试验速览
- 阶段
- 不适用
- 发起方
- 入组人数
- 10
- 试验地点
- 2
- 主要终点
- Change in myocardial blood flow by the race?
研究概览
简要总结
Ten healthy subjects perform a baseline computer tomography (CT) of the heart and routine laboratory blood tests for myocardial injury and inflammation.
The same data are collected <24 hours after an endurance race corresponding to a maraton run (i.e. about 40 km of running and/or about 2.5 hours hard training or more). A third collection of lab tests and CT is done a couple of weeks after the race. Magnetic resonance imaging is also performed in parallell to the CT on occasions 2 and 3 in most subjects, serving as a reference for determination of myocardial blood flow.
详细描述
Ten healthy subjects perform a baseline computer tomography (CT) of the heart and routine laboratory blood tests (troponin T, hs-CRP, CK-mb etc) for myocardial injury and inflammation.
The same data are collected <24 hours after an endurance race corresponding to a maraton run (i.e. about 40 km of running and/or about 2.5 hours hard training or more). A third collection of lab tests and CT is done a couple of weeks after the race. Magnetic resonance imaging (MRI) is also performed in parallell to the CT on occasions 2 and 3 in most subjects, serving as a reference for determination of myocardial blood flow. The CT of the heart includes contrast injection and blood flow will be determined by a recently developed based on very powerful computers using "machine learning".
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Diagnostic
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Healthy subjects, experienced in long distance running
排除标准
- •Significant renal, kidney, heart, liver or musculoskeletal disease.
研究组 & 干预措施
Endurance race
- baseline investigations with CT and lab tests
- the same CT and lab tests < 24h after an endurance race
- CT and lab tests again about 1-2weeks after the race
干预措施: Endurance Race (Behavioral)
结局指标
主要结局
Change in myocardial blood flow by the race?
时间窗: All investigations are performed < 2 months
Detection of potential differences in blood flow between occasion 1 and 2 and 3
次要结局
未报告次要终点
研究者
Fredrik H Nystrom
MD PhD professor head of internal medicine
University Hospital, Linkoeping