跳至主要内容
临床试验/NCT02894359
NCT02894359已完成不适用

Computer Modelling of the Cervical Spine Movements in Cervical Dystonia

Fondation Ophtalmologique Adolphe de Rothschild1 个研究点 分布在 1 个国家目标入组 21 人开始时间: 2016年10月27日最近更新:
适应症

试验速览

阶段
不适用
状态
已完成
入组人数
21
试验地点
1
主要终点
comparison of bone marks positions (degrees) in patients ans control motions

研究概览

简要总结

Cervical dystonia (CD) is a syndrome characterized by sustained and/or phasic involuntary neck muscle activity causing abnormal head postures and movements. It is the most frequent form of adult focal dystonia. The distribution of dystonic muscles is unique for each patient, explaining the variety of patterns encountered.

The therapeutic management of CD is essentially local and symptomatic: Botulinum Neurotoxin injections and/or specific retraining therapy programmes. Therefore, analyzing the characteristics of abnormal head movements and identifying the dystonic muscles are the key points of these treatments.

To a better understanding of the posture and movement disorders of head and neck, we wish to establish a three-dimensional (3-D) computer model of cervical spine movements of ten healthy subjects built from images obtained with the "Cone Beam " system. Then we will compare the cervical posture and movements for each of ten CD patients matched in age and genre to the computer model. Comparison with patients' images in the axial plane reconstructed by computer with the 3-D computer model will lead to the description of various patterns of CD. Analysis of the musculoskeletal disturbances in CD should be a help to improve the localization of Botulinum Neurotoxin injection sites as well as retraining programmes.

研究设计

研究类型
Observational
观察模型
Other
时间视角
Cross Sectional

入排标准

年龄范围
18 Years 至 70 Years(Adult, Older Adult)
性别
All
接受健康志愿者

入选标准

  • Tonic form of focal or segmental cervical dystonia (diagnostic confirmed by a neurologist specialized in movement disorders) for CD patients, or absence of CD for control subjects
  • absence of treatment by botulinum neurotoxin, or last injection > 3 months
  • age > 18 and < 71 years
  • informed consent
  • medical insurance coverage

排除标准

  • CD mobile (clonic) and/or head tremor
  • patient unable to sit without moving the head during the examination (x-ray pictures with cone beam)
  • Other neurological disease with effect on the posture and/or movement of the cervical region
  • Pain or traumatism of the cervical region requiring medical or surgical treatment in the preceding 6 months
  • Pregnant or breast feeding patient
  • Participation in another research with a potential impact on evaluation criteria
  • patient under judiciary protection

结局指标

主要结局

comparison of bone marks positions (degrees) in patients ans control motions

时间窗: baseline

positions measured in degrees with computerized imaging

次要结局

未报告次要终点

研究者

申办方类型
Network
责任方
Sponsor

研究点 (1)

Loading locations...

相似试验