Auditory Prediction and Error Evaluation in the Speech of Individuals Who Stutter
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 300
- 试验地点
- 2
- 主要终点
- change in speech when participants experience auditory errors
研究概览
简要总结
Stuttering negatively impacts communication and reduces the overall quality of life and well-being of individuals who stutter. This study will provide a strong foundation for developing neural and behavioral interventions for stuttering. Participants will be asked to name pictures, read words/sentences silently or aloud, and listen to speech and nonspeech sounds while their speech, muscle, and brain signals are collected. Some participants may also receive brain stimulation while reading and speaking.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Basic Science
- 盲法
- Double (Participant, Outcomes Assessor)
入排标准
- 年龄范围
- 3 Years 至 —（Child, Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •being a monolingual, native speaker of American English
- •absence of developmental, psychological, neurological, or communication disorders (other than developmental stuttering) as confirmed by a certified research SLP
- •normal (age-appropriate) binaural pure-tone hearing threshold (0.5-4k Hz; ≤25 dB HL for younger than 70 years, and ≤35 dB HL for older than 70 years)
- •not taking any medications that affect the central nervous system
- •absence of safety contra-indication for tDCS, TMS and MRI (for adults)
- •scoring at the 20th percentile or higher on standardized speech-language tests (for children)
排除标准
- 未提供
研究组 & 干预措施
Group 1
干预措施: Delaying speech initiation (Behavioral)
Group 2
干预措施: Auditory errors and pre-speech auditory modulation (Behavioral)
Group 3
干预措施: Contributions of the speech premotor cortex to pre-speech auditory modulation (Behavioral)
Group 4
干预措施: Delaying auditory feedback (Behavioral)
结局指标
主要结局
change in speech when participants experience auditory errors
时间窗: within each session of the study that may last up to 2 hours
In each trial, participants will experience an auditory error while they produce speech (e.g., they may say "head" but hear "had"). The investigators will measure how the participants' speech changes due to auditory errors that they experience in the current trial. For this p\[purpose, the investigators will use commercial microphones to record speech signals and then examine the amplitude of the speech in specific frequency ranges (measured in Hertz; Hz). The frequencies (Hz) of speech in trials with auditory errors will be compared with those without auditory errors.
Change in brain activity before and during speaking
时间窗: within each session of the study that may last up to 2 hours
Participants will hear speech sounds in each trial before speaking or reading words. Participants' brain activity will be recorded while completing the speaking or reading tasks. The investigators will measure how the participant's brain activity in response to the played sounds changes during speaking and reading tasks. For this purpose, the investigators will measure the amplitude of the brain activity (in microvolts; µV) measured using a commercial electroencephalography system. The amplitude (µV) of the brain signals will be examined both before speaking and during speaking at two time points.
次要结局
未报告次要终点