Modification of the Gut Microbiota Following the Consumption of Inulin-rich Vegetables: Effect on Gut Tolerance, Transit, Behaviour and Digestion in Healthy Humans
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 26
- 主要终点
- Gut microbiota composition
研究概览
简要总结
Inulin-type fructans (ITF) are fermentable dietary fibres that can confer beneficial health effects through changes in the gut microbiota. However, their effect on gut sensitivity and nutritional behaviour is a matter of debate.
The investigators evaluated, in healthy individuals, the impact of shifting from their usual food habits towards a diet based on the daily consumption of ITF-rich vegetables on gut microbiota, gastro-intestinal symptoms and food-related behaviour.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Other
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 85 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •BMI between 20 and 25 kg/m²
- •Caucasian ethnicity
- •Hydrogen producers (assessed by hydrogen breath test)
排除标准
- •Laxative consumption (<4 weeks)
- •Severe intestinal problems
- •Psychiatric problems or use of antipsychotic
- •Consumption of antibiotics, pro/prebiotics, fibre dietary supplement, or any molecules that modifies the intestinal transit (<6 weeks)
- •Specific dietary practise (vegetarian, vegan,...)
- •Specific dietary treatment (<6 weeks) (e.g. high protein diet)
- •Excessive alcohol consumption (>3 glasses/day)
- •Consumption of the following drugs: proton pump inhibitor, antidiabetic drugs, cholesterol lowering drugs
- •Inconclusive acceptability test (regarding the protocol of the intervention and the vegetables used in the protocol)
研究组 & 干预措施
Dietary intervention
干预措施: Diet based on inulin-rich vegetables (Other)
结局指标
主要结局
Gut microbiota composition
时间窗: 33 days
Gut microbiota composition is assessed by 16S rRNA pyrosequencing. This analysis allows to obtain the relative abundance (%) of the different bacterial taxa and OTUs (operational taxonomic units).
次要结局
- Gastrointestinal Symptoms(33 days)
- Gut microbiota fermentation in vivo(33 days)
- Appetite-related feelings(33 days)
- Correlation of gastrointestinal symptoms with gut bacteria(33 days)
- Short chain fatty acids production(14 days)
- Gut microbiota fermentation in vitro(14 days)