The Prognostic Significance of Fibrosis Detection in Ischemic and Non-ischemic Cardiomyopathy
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 3,000
- 试验地点
- 1
- 主要终点
- All cause mortality
研究概览
简要总结
The presence of scar within heart muscle can act as a substrate for abnormal rhythm problems and lead to the developement of heart failure
Clinical significance Correlation with biomarkers and genetic markers
详细描述
Patients will undergo cardiovascular magnetic resonance (CMR) to include measurement of left ventricular volumes, ejection fraction, detection of inflammation (via STIR sequences) where appropriate, early gadolinium enhancement, late gadolinium enhancement, first pass perfusion using pharmacological stress imaging (contraindications to include comorbidities that do not permit pharmacological stress agents e.g. severe asthma, severe or symptomatic aortic stenosis)
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •presence of an ischaemic or non-ischaemic cardiomyopathic process
- •no contraindication to contrast enhanced CMR
排除标准
- •Contraindication to CM R
结局指标
主要结局
All cause mortality
时间窗: 3 years
Ventricular arrhythmias
时间窗: 3 years
Unplanned heart failure admissions
时间窗: 3 years
次要结局
- Ejection fraction(3)
- NYHA status(3)
研究者
Sanjay Prasad
Consultant Cardiologist
Royal Brompton & Harefield NHS Foundation Trust