Non-Contrast CT vs CTP or MRI Selection vs Medical Management in Late Presentation of Large Vessel Occlusion Stroke, 6-24 Hours. A Multicenter Retrospective Study
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 2,790
- 试验地点
- 19
- 主要终点
- Change in patients' disability based on a Modified Rankin Scale
研究概览
简要总结
The objective of this multicenter, retrospective, cross-sectional, chart review study is to compare outcomes (disability, complications and mortality) of patients with large vessel occlusion stroke presenting at late time window selected by either Non-Contrast CT (NCCT) only, advanced imaging with CTP (Computed Tomography Perfusion), MRI (Magnetic Resonance Imaging), or medical management.
Boston Medical Center (BMC) will serve as the main data coordinating site. Fifteen additional sites will seek local IRB approval or ethics approval. The aggregated de-identified data will be analyzed comparing types of interventions and outcomes by type of imaging or medical management.
详细描述
Additional subgroup analysis that are planned include:
- Futile Reperfusion in the Extended Window.
We will evaluate clinical, imaging and time metric factors associated with successful reperfusion yet poor outcomes (modified Rankin 3-6) in the 6-24 hour window.
An evaluation of factors associated with symptomatic intracranial hemorrhage and mortality will be conducted. 2. Pre-Stroke disability.
- EVT patients treated in the extended window compared to Medical Management
- EVT patients treated in the extended window with pre-existing disability vs. those without pre-existing disability
- Intravenous Thrombolysis in the Extended Window
研究设计
- 研究类型
- Observational
- 观察模型
- Other
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients presenting 6-24 hours from last known well with large vessel occlusion stroke
- •ASPECTS score 5 or greater from last known well
- •January 1, 2014 to May 1, 2022
排除标准
- •Time last seen well to treatment <6 hours from last known well
结局指标
主要结局
Change in patients' disability based on a Modified Rankin Scale
时间窗: baseline, 90 days
The Modified Rankin Score (mRS) is a 6 point disability scale with possible scores ranging from 0 to 5. Lower scores correlate with less disability/dependence.
次要结局
- Intracranial hemorrhage incidence(90 days)
- Mortality rate(90 days)