ISRCTN18135766已完成Unknown
Effectiveness of hypertension management with an amlodipine and perindopril arginine-based strategy in Morocco
SERVIER (Morocco)0 个研究点目标入组 1,614 人开始时间: 2024年4月5日最近更新:
适应症
试验速览
- 阶段
- Unknown
- 状态
- 已完成
- 发起方
- 入组人数
- 1,614
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Observational
入排标准
- 性别
- All
入选标准
- •1. Men or women aged =18 years who document informed consent.
- •2. Hypertensive patients previously treated with amlodipine monotherapy, uncontrolled and for whom the treating physician decides to add perindopril arginine.
排除标准
- •1.Age < 18 years
- •2.Pregnancy, breastfeeding or possibility of becoming pregnant during the study
- •3.Current participation in another randomized study or within the previous 3 months
- •4.Known symptomatic orthostatic hypotension
- •5.Known hyperkalemia or hypokalemia
- •6.History of arterial hypertension known to be resistant to the free combination or in a single tablet with perindopril and calcium channel blockers or contraindications to treatment with perindopril or amlodipine
- •7.Known secondary hypertension or complicated hypertension
- •8.Known renal insufficiency: patients with a creatinine clearance value classifying them as moderate or severe renal insufficiency according to the national or international classification of chronic renal insufficiency or bilateral stenosis of the renal artery or stenosis at solitary kidney or history of gout
- •9.Known complicated liver disease
- •10.Chronic pancreatitis
- •11.History of heart disease: cardiogenic shock, myocardial infarction within 6 months prior to selection, hemodynamically unstable heart failure after acute myocardial infarction, coronary revascularization within 6 months previous congestive heart failure within 6 months prior to selection or history of congestive heart failure with NYHA grade III or IV, severe aortic or mitral valve stenosis or hypertrophic obstructive cardiomyopathy
- •12.Recent ventricular rhythm disorders
- •13.History of cerebrovascular disease
- •14.Hypersensitivity to active substances, other sulfonamides, dihydropyridine derivatives and any ACE inhibitors
- •15.History of angioedema (angioedema) associated with previous treatment with an ACE inhibitor
- •16.Hereditary/idiopathic angioedema
- •17.Hepatic encephalopathy
- •18.Concomitant use of the fixed combination of perindopril and amlodipine with products containing aliskiren in patients with diabetes mellitus or renal insufficiency (GFR < 60 ml/min/1.73 m²)
- •19.Any other contraindication according to the SPC (Summary of Product Characteristics) of the medicinal product.
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