Efficacy of Medical Therapy for Pulmonary Arterial and Inoperable Chronic Thromboembolic Pulmonary Hypertension in a Real Life Setting
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 313
- 试验地点
- 1
- 主要终点
- Change in NT-proBNP
研究概览
简要总结
The collected data from the Zurich Registry for pulmonary Hypertension (PH) are evaluated in a retrospective analysis. This study examines the number of patients and their exact diagnoses who are treated at the University Hospital of Zurich and potentially other participating in the Zurich Registry. Other demographic parameters such as age, gender and body-mass-index are also part of the evaluation. Furthermore, the analysis will focus on the newest guidelines on PH. Therefore, it will be checked how many patients would fulfill the therapeutic goals in terms of New York Heart Classification (NYHA), 6-minute walk distance, sign of right heart failure and N-terminal pro-brain-natriuretic peptide(NTproBNP). Additionally, the study examines on how the patients are treated. Despite the different kind of Drugs, the focus lies on the combination therapy (single, double, triple) and the impact the therapy had on the patients.
研究设计
- 研究类型
- Observational
- 观察模型
- Other
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 18 Years 至 —(Adult, Older Adult)
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients with pulmonary arterial hypertension (PAH)
- •Patients with chronic thromboembolic pulmonary hypertension (CTEPH)
- •All prevalent patients (diagnosed >12 month ago) with PAH or distal CTEPH who had a consultation at the PH centre in Zurich between November 2015 and November 2016)
排除标准
- 未提供
结局指标
主要结局
Change in NT-proBNP
时间窗: Baseline, 3 months, 6 months, 1 year
Change of the 6 minute walk distance over time in relation to given vasodilator treatment
Change in NYHA/WHO functional class
时间窗: Baseline, 3 months, 6 months, 1 year
Change of the functional class over time in relation to given vasodilator treatment
Change in 6 minute walk distance
时间窗: Baseline, 3 months, 6 months, 1 year
Change of the 6 minute walk distance over time in relation to given vasodilator treatment
次要结局
- Percentage of patients with a 6 minute walk distance > 440m(Baseline, 3 months, 6 months, 1 year)
- Percentage of patients that are in NYHA/WHO functional class <= II(Baseline, 3 months, 6 months, 1 year)
- Percentage of patients with a NT-proBNP < 300 ng/l(Baseline, 3 months, 6 months, 1 year)
