Comparative evaluation of Simvastatin Gel infused in commercially available bone graft in healing after surgical removal of impacted third molars – Split mouth study.

Challenges associated with the extraction of third molars, includes alveolar bone resorption and soft tissue changes. Various techniques have been employed to mitigate these issues, such as alveolar ridge preservation using biocompatible materials. Among these materials, anorganic xenografts have shown promise due to their similarity to human bone and ability to enhance bone formation.

Furthermore, statins, particularly simvastatin, have been extensively studied for their role in bone regeneration. Simvastatin has been shown to increase bone morphogenetic protein-2 (BMP-2) expression, leading to enhanced osteoblastic activity and inhibition of osteoclastic activity, ultimately promoting bone formation while also possessing anti-inflammatory properties.

The study’s goal is to evaluate the combined effect of simvastatin gel and the commercially available xenograft "RegenerOss Synthetic" on healing after the surgical removal of impacted third molars, a novel approach not previously explored in the literature. This evaluation aims to leverage the synergistic potential of simvastatin’s osteogenic and anti-inflammatory properties along with the biocompatibility and scaffold-like structure of RegenerOss Synthetic to optimize bone regeneration and soft tissue healing post-extraction.