Improving primary care antibiotic prescribing to reduce antibiotic resistant urine infections: the IPAP-UTI series of cluster randomised controlled trials

niversity of Bristol0 个研究点目标入组 20 人开始时间: 2024年8月15日最近更新: 2024年8月26日

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•This is a cluster RCT and individual patients are not recruited. Data for the study will only include male and female patients, aged 16 years and over.
•Inclusion criteria for ICBs:
•ICBs in England are eligible for the study if they are actively contributing to the UKHSA voluntary national surveillance of UTI AMR. See master protocol, supplementary material A for further details of ICB selection criteria, which was developed to assess ICB eligibility based on UKHSA routinely collected national UTI AMR data, and UKHSA national antibiotic dispensing data (both datasets at ICB and GP practice level).
•Inclusion criteria for GP practices:
•GP practices will be eligible if providing within office hours standard NHS care. We will consider additional eligibility criteria where necessary, including restricting to NHS GP practices where:
•1. >=40% of registered patients are female
•2. There are at least 100 registered patients
•GP practices supporting individually randomised patient RCTs of different antibiotics for UTIs may take part in the IPAP-UTI RCTs.
•Qualitative interviews:
•A purposive sample, of up to 20 prescribing clinicians and ICB staff involved in implementation of the intervention will be recruited to take part in interviews for the qualitative process evaluation. We will aim for a maximum diversity sample in terms of practice population diversity, to ensure data is captured from a range of settings.

•1. ICBs taking, or planning to take, part in other cluster RCTs involving an intervention to change antibiotic prescribing for UTIs will be excluded.
•2. GP practices taking part in other cluster RCTs involving an intervention to change antibiotic prescribing for UTIs will be excluded.
•3. The routinely collected data used in the RCTs will be restricted to male and female patients aged 16 years and over.

发起方

niversity of Bristol