Inappropriate Prescribing of Proton-pump Inhibitor is it Associated With the Burden of Comorbidities in Older Patients Over 75 Years Old ?
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 280
- 试验地点
- 1
- 主要终点
- Burden of comorbidities
研究概览
简要总结
Proton pump inhibitors (PPIs) are one of the most frequently prescribed classes of drugs in the world and the most effective drugs available to reduce gastric acid secretion. However, studies have shown that PPIs are not always prescribed with a clear indication. Indeed, between 25% and 86% of older individuals taking a PPI have been overprescribed these medications. In older patients, overprescribing of a PPI is associated with increases in morbidity, adverse drug events, hospitalization, and mortality. The hypothesis is that overprescription of PPIs is associated with the individual multimorbidities in older patients evaluated using the multimorbidities group criteria included in the CIRS. The aim of the present study was to establish a relationship between overprescribing of PPIs and multimorbidities in older patients.
研究设计
- 研究类型
- Observational
- 时间视角
- Prospective
入排标准
- 年龄范围
- 75 Years 至 —（Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients of 75 years or more
- •Patients hospitalized in geriatric short stay
- •Patients with an inhibitor therapy proton pump short geriatric entry
- •Patients who have given their written consent
排除标准
- •Patients who have expressed their inability or refusal to sign an informed consent
结局指标
主要结局
Burden of comorbidities
时间窗: 48 hours after the entry into acute geriatric medicine
Burden of comorbidities is assessed by the CIRS (Cumulative Illness Rating Scale)
次要结局
未报告次要终点